Details of the Target
General Information of Target
| Target ID | LDTP10817 | |||||
|---|---|---|---|---|---|---|
| Target Name | Glutathione peroxidase 7 (GPX7) | |||||
| Gene Name | GPX7 | |||||
| Gene ID | 2882 | |||||
| Synonyms |
GPX6; Glutathione peroxidase 7; GPx-7; GSHPx-7; EC 1.11.1.9; CL683 |
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| 3D Structure | ||||||
| Sequence |
MGSRWSSEEERQPLLGPGLGPGLGASWRSREAAAAALPAAVPGPGRVYGRRWLVLLLFSL
LAFVQGLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLPCFAFMWLLDKRGLRITV LLTSFLMVLGTGLRCIPISDLILKRRLIHGGQMLNGLAGPTVMNAAPFLSTTWFSADERA TATAIASMLSYLGGACAFLVGPLVVPAPNGTSPLLAAESSRAHIKDRIEAVLYAEFGVVC LIFSATLAYFPPRPPLPPSVAAASQRLSYRRSVCRLLSNFRFLMIALAYAIPLGVFAGWS GVLDLILTPAHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGMLKLILLLLFSGATLS STWFTLTCLNSITHLPLTTVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVV TFLSNMFMGVLLFFLTFYHTELSWFNWCLPGSCLLSLLLILCFRESYDRLYLDVVVSV |
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| Target Bioclass |
Enzyme
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| Family |
Glutathione peroxidase family
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| Subcellular location |
Secreted
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| Function |
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxygen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C86(0.47) | LDD3332 | [1] | |
Competitor(s) Related to This Target