Details of the Target

General Information of Target

Target ID LDTP10813
Target Name T-box transcription factor TBX15 (TBX15)
Gene Name TBX15
Gene ID 6913
Synonyms
TBX14; T-box transcription factor TBX15; T-box protein 15; T-box transcription factor TBX14; T-box protein 14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLY
CSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSV
MFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSRE
ECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPE
ILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRK
TNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCR
SSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTA
VSEKQPEKLRQTPGCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQ
KADGDVPQWEVFFKRNDEITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQS
THITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKADYRPTIKENIPASLMEQNVICPKD
TYSDLKSRDKDVTIVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAE
LPKREHLQYLYEKLATGESIAVKKRKCSLLDT
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes.
Uniprot ID
Q96SF7
Ensemble ID
ENST00000207157.7
HGNC ID
HGNC:11594

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.S510F .
HCT116 SNV: p.V196A .
HCT15 SNV: p.S236Y .
HT115 SNV: p.S491P; p.F496Y .
ICC3 SNV: p.K300Ter .
IGR1 SNV: p.R303K .
MCAS SNV: p.G458D .
MCC26 SNV: p.P325S .
MFE296 Deletion: p.N380TfsTer15 .
NB1 SNV: p.S179I .
NCIH1792 SNV: p.E37D .
NCIH2286 SNV: p.N395S .
RKO SNV: p.Y160C .
SKMEL24 SNV: p.S525F .
SNU1 SNV: p.G54R .
SUPT1 SNV: p.V599M .
TOV21G SNV: p.G355W; p.A589V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C392(0.97); C402(0.97)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C392(0.97); C402(0.97)  LDD0078  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.