Details of the Target
General Information of Target
| Target ID | LDTP10800 | |||||
|---|---|---|---|---|---|---|
| Target Name | Dual specificity testis-specific protein kinase 2 (TESK2) | |||||
| Gene Name | TESK2 | |||||
| Gene ID | 10420 | |||||
| Synonyms |
Dual specificity testis-specific protein kinase 2; EC 2.7.12.1; Testicular protein kinase 2 |
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| 3D Structure | ||||||
| Sequence |
MAAAGAAATHLEVARGKRAALFFAAVAIVLGLPLWWKTTETYRASLPYSQISGLNALQLR
LMVPVTVVFTRESVPLDDQEKLPFTVVHEREIPLKYKMKIKCRFQKAYRRALDHEEEALS SGSVQEAEAMLDEPQEQAEGSLTVYVISEHSSLLPQDMMSYIGPKRTAVVRGIMHREAFN IIGRRIVQVAQAMSLTEDVLAAALADHLPEDKWSAEKRRPLKSSLGYEITFSLLNPDPKS HDVYWDIEGAVRRYVQPFLNALGAAGNFSVDSQILYYAMLGVNPRFDSASSSYYLDMHSL PHVINPVESRLGSSAASLYPVLNFLLYVPELAHSPLYIQDKDGAPVATNAFHSPRWGGIM VYNVDSKTYNASVLPVRVEVDMVRVMEVFLAQLRLLFGIAQPQLPPKCLLSGPTSEGLMT WELDRLLWARSVENLATATTTLTSLAQLLGKISNIVIKDDVASEVYKAVAAVQKSAEELA SGHLASAFVASQEAVTSSELAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSLVKI FLETRKSWRKPEKTD |
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| Target Type |
Literature-reported
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| Target Bioclass |
Enzyme
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| Family |
Protein kinase superfamily, TKL Ser/Thr protein kinase family
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| Subcellular location |
Nucleus
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| Function |
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.
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| TTD ID | ||||||
| Uniprot ID | ||||||
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| Ensemble ID | ||||||
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| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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HHS-475 Probe Info |
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Y386(0.93); Y387(1.01) | LDD0264 | [1] | |
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HHS-465 Probe Info |
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N.A. | LDD2240 | [2] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0116 | HHS-0101 | DM93 | Y386(0.93); Y387(1.01) | LDD0264 | [1] |
| LDCM0117 | HHS-0201 | DM93 | Y386(0.91); Y387(0.94) | LDD0265 | [1] |
| LDCM0118 | HHS-0301 | DM93 | Y386(0.92); Y387(1.05) | LDD0266 | [1] |
| LDCM0119 | HHS-0401 | DM93 | Y386(1.13); Y387(1.28) | LDD0267 | [1] |
| LDCM0120 | HHS-0701 | DM93 | Y386(1.01); Y387(1.14) | LDD0268 | [1] |
References