Details of the Target
General Information of Target
| Target ID | LDTP10794 | |||||
|---|---|---|---|---|---|---|
| Target Name | Ras-related protein Rab-40C (RAB40C) | |||||
| Gene Name | RAB40C | |||||
| Gene ID | 57799 | |||||
| Synonyms |
RARL; RASL8C; Ras-related protein Rab-40C; Rar-like protein; Ras-like protein family member 8C; SOCS box-containing protein RAR3 |
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| 3D Structure | ||||||
| Sequence |
MAPASRLLALWALAAVALPGSGAEGDGGWRPGGPGAVAEEERCTVERRADLTYAEFVQQY
AFVRPVILQGLTDNSRFRALCSRDRLLASFGDRVVRLSTANTYSYHKVDLPFQEYVEQLL HPQDPTSLGNDTLYFFGDNNFTEWASLFRHYSPPPFGLLGTAPAYSFGIAGAGSGVPFHW HGPGYSEVIYGRKRWFLYPPEKTPEFHPNKTTLAWLRDTYPALPPSARPLECTIRAGEVL YFPDRWWHATLNLDTSVFISTFLG |
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| Target Bioclass |
Enzyme
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| Family |
Small GTPase superfamily, Rab family
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| Subcellular location |
Cell membrane
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| Function |
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C273(1.43) | LDD2265 | [1] | |
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TFBX Probe Info |
 |
N.A. | LDD0027 | [2] | |
|
IPM Probe Info |
 |
N.A. | LDD2156 | [3] | |
|
AOyne Probe Info |
 |
10.70 | LDD0443 | [4] | |
Competitor(s) Related to This Target
References