Details of the Target
General Information of Target
| Target ID | LDTP10737 | |||||
|---|---|---|---|---|---|---|
| Target Name | Germ cell nuclear acidic protein (GCNA) | |||||
| Gene Name | GCNA | |||||
| Gene ID | 93953 | |||||
| Synonyms |
ACRC; Germ cell nuclear acidic protein; Acidic repeat-containing protein; Germ cell nuclear acidic peptidase; Germ cell nuclear antigen |
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| 3D Structure | ||||||
| Sequence |
MGLKKMKGLSYDEAFAMANDPLEGFHEVNLASPTSPDLLGVYESGTQEQTTSPSVIYRPH
PSALSSVPIQANALDVSELPTQPVYSSPRRLNCAEISSISFHVTDPAPCSTSGVTAGLTK LTTRKDNYNAEREFLQGATITEACDGSDDIFGLSTDSLSRLRSPSVLEVREKGYERLKEE LAKAQRELKLKDEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKE AQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDL SVIQPIVKDCKEADLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAV LEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKSCKHRIKLGDSSNYYYIS PFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKEEL |
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| Target Bioclass |
Transcription factor
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| Family |
Serine-aspartate repeat-containing protein (SDr) family
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| Subcellular location |
Nucleus
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| Function |
May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage. Can resolve the topoisomerase II (TOP2A) DPCs.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K482(5.26) | LDD0277 | [1] | |
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NAIA_5 Probe Info |
 |
C557(1.22) | LDD2228 | [2] | |
Competitor(s) Related to This Target
References