Details of the Target

General Information of Target

Target ID LDTP10722
Target Name Transmembrane protein 237 (TMEM237)
Gene Name TMEM237
Gene ID 65062
Synonyms
ALS2CR4; Transmembrane protein 237; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG
EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA
GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL
GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI
TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS
VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED
SEHGEKPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK
VMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR
RLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG
HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV
PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPV
LLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPL
LSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLD
SYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLP
IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFP
GKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLW
AEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSG
SSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL
EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS
GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEG
NFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKIT
GTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDN
IAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPL
HPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTI
PLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDRE
EDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQ
QISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSE
VHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN
Target Bioclass
Transporter and channel
Family
TMEM237 family
Subcellular location
Membrane
Function Component of the transition zone in primary cilia. Required for ciliogenesis.
Uniprot ID
Q96Q45
Ensemble ID
ENST00000409444.6
HGNC ID
HGNC:14432

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.A189V .
LS180 Deletion: p.S184AfsTer12 .
SNU1 Deletion: p.P45QfsTer101 .
T24 SNV: p.R192H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0233  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0233  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylserine lipase ABHD16A (ABHD16A) ABHD16 family O95870
Inactive pancreatic lipase-related protein 1 (PNLIPRP1) Lipase family P54315
Phosphatidate cytidylyltransferase 1 (CDS1) CDS family Q92903
Cytochrome b5 type B (CYB5B) Cytochrome b5 family O43169
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) Glycosyltransferase 13 family Q8WZA1
Exostosin-like 1 (EXTL1) Glycosyltransferase 47 family Q92935
Phospholipid phosphatase-related protein type 2 (PLPPR2) PA-phosphatase related phosphoesterase family Q96GM1
Endoplasmic reticulum metallopeptidase 1 (ERMP1) Peptidase M28 family Q7Z2K6
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) . Q12982
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) . Q9NWM8
Transporter and channel
Click To Hide/Show 45 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cationic amino acid transporter 3 (SLC7A3) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family Q8WY07
High affinity cationic amino acid transporter 1 (SLC7A1) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family P30825
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) Amino acid/polyamine transporter 2 family Q96QD8
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) Amino acid/polyamine transporter 2 family Q9NVC3
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Claudin-4 (CLDN4) Claudin family O14493
Gap junction beta-2 protein (GJB2) Connexin family P29033
Protein cornichon homolog 3 (CNIH3) Cornichon family Q8TBE1
ER membrane protein complex subunit 6 (EMC6) EMC6 family Q9BV81
FXYD domain-containing ion transport regulator 6 (FXYD6) FXYD family Q9H0Q3
Glycophorin-A (GYPA) Glycophorin A family P02724
Insulin-induced gene 1 protein (INSIG1) INSIG family O15503
Insulin-induced gene 2 protein (INSIG2) INSIG family Q9Y5U4
Transmembrane 4 L6 family member 19 (TM4SF19) L6 tetraspanin family Q96DZ7
Molybdate-anion transporter (MFSD5) Major facilitator superfamily Q6N075
Major facilitator superfamily domain-containing protein 6 (MFSD6) MFSD6 family Q6ZSS7
Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5) Sugar transporter (TC 2.A.1.1) family P22732
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Membrane-spanning 4-domains subfamily A member 13 (MS4A13) MS4A family Q5J8X5
Probable UDP-sugar transporter protein SLC35A4 (SLC35A4) Nucleotide-sugar transporter family Q96G79
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) Nucleotide-sugar transporter family Q8TB61
Nucleotide sugar transporter SLC35B4 (SLC35B4) Nucleotide-sugar transporter family Q969S0
Proton channel OTOP2 (OTOP2) Otopetrin family Q7RTS6
Proton channel OTOP3 (OTOP3) Otopetrin family Q7RTS5
Solute carrier family 52, riboflavin transporter, member 1 (SLC52A1) Riboflavin transporter family Q9NWF4
Solute carrier family 41 member 1 (SLC41A1) SLC41A transporter family Q8IVJ1
Solute carrier family 41 member 2 (SLC41A2) SLC41A transporter family Q96JW4
Probable glucose sensor protein SLC5A4 (SLC5A4) Sodium:solute symporter (SSF) (TC 2.A.21) family Q9NY91
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Uroplakin-1b (UPK1B) Tetraspanin (TM4SF) family O75841
Transmembrane 6 superfamily member 2 (TM6SF2) TM6SF family Q9BZW4
Transmembrane protein 144 (TMEM144) TMEM144 family Q7Z5S9
BOS complex subunit TMEM147 (TMEM147) TMEM147 family Q9BVK8
Transmembrane protein 179B (TMEM179B) TMEM179 family Q7Z7N9
Solute carrier family 35 member G1 (SLC35G1) TMEM20 family Q2M3R5
Solute carrier family 35 member E4 (SLC35E4) TPT transporter family Q6ICL7
Protein unc-93 homolog B1 (UNC93B1) Unc-93 family Q9H1C4
Zinc transporter ZIP2 (SLC39A2) ZIP transporter (TC 2.A.5) family Q9NP94
Zinc transporter ZIP9 (SLC39A9) ZIP transporter (TC 2.A.5) family Q9NUM3
Adiponectin (ADIPOQ) . Q15848
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) . Q9NWW5
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (STRIT1) . P0DN84
Transmembrane protein 60 (TMEM60) . Q9H2L4
Transmembrane protein 72 (TMEM72) . A0PK05
GPCR
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Delta-type opioid receptor (OPRD1) G-protein coupled receptor 1 family P41143
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Lysophosphatidic acid receptor 3 (LPAR3) G-protein coupled receptor 1 family Q9UBY5
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Probable G-protein coupled receptor 25 (GPR25) G-protein coupled receptor 1 family O00155
Metabotropic glutamate receptor 2 (GRM2) G-protein coupled receptor 3 family Q14416
Frizzled-7 (FZD7) G-protein coupled receptor Fz/Smo family O75084
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Butyrophilin subfamily 2 member A2 (BTN2A2) BTN/MOG family Q8WVV5
Roundabout homolog 2 (ROBO2) ROBO family Q9HCK4
Cytokine and receptor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C motif chemokine 9 (CXCL9) Intercrine alpha (chemokine CxC) family Q07325
Lymphotoxin-alpha (LTA) Tumor necrosis factor family P01374
Interferon gamma receptor 1 (IFNGR1) Type II cytokine receptor family P15260
Other
Click To Hide/Show 31 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BET1 homolog (BET1) BET1 family O15155
Bladder cancer-associated protein (BLCAP) BLCAP family P62952
Apolipoprotein D (APOD) Lipocalin family P05090
Ephrin-A5 (EFNA5) Ephrin family P52803
Cobalamin binding intrinsic factor (CBLIF) Eukaryotic cobalamin transport proteins family P27352
Guanylin (GUCA2A) Guanylin family Q02747
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Low-density lipoprotein receptor-related protein 10 (LRP10) LDLR family Q7Z4F1
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
ORM1-like protein 3 (ORMDL3) ORM family Q8N138
Stress-associated endoplasmic reticulum protein 2 (SERP2) RAMP4 family Q8N6R1
Protein reprimo (RPRM) Reprimo family Q9NS64
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
RUS family member 1 (RUSF1) RUS1 family Q96GQ5
Plasminogen activator inhibitor 1 (SERPINE1) Serpin family P05121
Sideroflexin-5 (SFXN5) Sideroflexin family Q8TD22
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Transmembrane protein 11, mitochondrial (TMEM11) TMEM11 family P17152
Tomoregulin-2 (TMEFF2) Tomoregulin family Q9UIK5
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
Immediate early response 3-interacting protein 1 (IER3IP1) YOS1 family Q9Y5U9
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
Coiled-coil domain-containing protein 167 (CCDC167) . Q9P0B6
Complement factor H-related protein 5 (CFHR5) . Q9BXR6
Gastrokine-2 (GKN2) . Q86XP6
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
TPA-induced transmembrane protein (TTMP) . Q5BVD1
Transmembrane protein 107 (TMEM107) . Q6UX40
Transmembrane protein 254 (TMEM254) . Q8TBM7
Transmembrane protein 42 (TMEM42) . Q69YG0

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.