Details of the Target

General Information of Target

Target ID LDTP10711
Target Name CUB and sushi domain-containing protein 1 (CSMD1)
Gene Name CSMD1
Gene ID 64478
Synonyms
KIAA1890; CUB and sushi domain-containing protein 1; CUB and sushi multiple domains protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSCKKQRSRKHSVNEKCNMKIEHYFSPVSKEQQNNCSTSLMRMESRGDPRATTNTQAQRF
HSPKKNPEDQTMPQNRTIYVTLKVNHRRNQDMKLKLTHSENSSLYMALNTLQAVRKEIET
HQGQEMLVRGTEGIKEYINLGMPLSCFPEGGQVVITFSQSKSKQKEDNHIFGRQDKASTE
CVKFYIHAIGIGKCKRRIVKCGKLHKKGRKLCVYAFKGETIKDALCKDGRFLSFLENDDW
KLIENNDTILESTQPVDELEGRYFQVEVEKRMVPSAAASQNPESEKRNTCVLREQIVAQY
PSLKRESEKIIENFKKKMKVKNGETLFELHRTTFGKVTKNSSSIKVVKLLVRLSDSVGYL
FWDSATTGYATCFVFKGLFILTCRHVIDSIVGDGIEPSKWATIIGQCVRVTFGYEELKDK
ETNYFFVEPWFEIHNEELDYAVLKLKENGQQVPMELYNGITPVPLSGLIHIIGHPYGEKK
QIDACAVIPQGQRAKKCQERVQSKKAESPEYVHMYTQRSFQKIVHNPDVITYDTEFFFGA
SGSPVFDSKGSLVAMHAAGFAYTYQNETRSIIEFGSTMESILLDIKQRHKPWYEEVFVNQ
QDVEMMSDEDL
Target Bioclass
Other
Family
CSMD family
Subcellular location
Membrane
Function Potential suppressor of squamous cell carcinomas.
Uniprot ID
Q96PZ7
Ensemble ID
ENST00000635120.2
HGNC ID
HGNC:14026

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.N2986H .
A375 SNV: p.G1014E; p.E1836K .
BXPC3 SNV: p.G1474E .
CAL72 SNV: p.S925R .
CAMA1 SNV: p.G1453W .
CCLP1 SNV: p.Y828F .
CCSW1 SNV: p.S2101Ter .
COLO800 SNV: p.S218F; p.G3446R .
DEL SNV: p.E1562K .
DU145 SNV: p.T64K; p.R320I; p.V611F; p.N1184K; p.Y3480C .
EFO27 SNV: p.H794R .
FADU Deletion: p.L2061TfsTer36 .
HCC1395 SNV: p.G2541V .
HCC1806 SNV: p.V650I .
HCC44 SNV: p.R2674L .
HCT116 Deletion: p.L1067DfsTer45
SNV: p.F2831I		 .
HCT15 SNV: p.G1079C; p.G2074R; p.P2461L; p.A2644S; p.G2800C; p.L3166F .
HEC1 SNV: p.L1183P .
HEC1B SNV: p.L1183P .
HEP3B217 SNV: p.F1438L .
HGC27 SNV: p.S338R .
HS936T SNV: p.R3244K .
HT SNV: p.T904A .
HT115 SNV: p.E2194K; p.R3192G; p.A3498V .
IGR1 SNV: p.R1076C .
IGR37 SNV: p.R1145I; p.S1993F .
IGR39 SNV: p.S1993F .
IGROV1 SNV: p.S2381P; p.S2858P .
IM95 SNV: p.R1055L; p.C2588F .
IPC298 SNV: p.P355S; p.E562K; p.E603K; p.D908N; p.S2241L; p.S2716F; p.G2835E .
JURKAT SNV: p.S1070Y; p.P2163L .
JURLMK1 SNV: p.I2351V .
KASUMI1 SNV: p.W195C .
KATOIII SNV: p.G1928R .
KMCH1 SNV: p.P148T; p.F3185Y .
KMS11 SNV: p.L1691I .
KMS27 SNV: p.P1785S; p.N2400H .
KYSE150 SNV: p.G1750R; p.S2055R .
KYSE410 SNV: p.S1038Ter; p.P2615Q .
LS180 SNV: p.N1119H .
LUDLU1 SNV: p.Y1502N .
MCC13 SNV: p.G340R; p.P425S; p.S1029L; p.E1766K .
MDAMB231 SNV: p.P818L; p.P1485Q .
MDST8 SNV: p.H1303Y; p.G3106E .
MEWO SNV: p.S1029L; p.R1076C; p.R1529K; p.G1839E; p.G1928R; p.G2742V; p.P2971L; p.A3133V; p.E3526K .
MFE296 SNV: p.V3239F .
MKN1 SNV: p.Q1893K .
MOLT4 SNV: p.T1574A .
NCIH1666 SNV: p.W289C .
NCIH1703 SNV: p.G2728V .
NCIH1793 SNV: p.V1092L .
NCIH196 SNV: p.Q372E .
NCIH1993 SNV: p.E562Ter .
NCIH2052 Deletion: p.L325SfsTer2 .
NCIH2286 SNV: p.G967V; p.D1393Y .
NCIH2291 SNV: p.F1556I .
NCIH23 SNV: p.A2866S .
NCIH661 Deletion: p.G104DfsTer8 .
OAW28 SNV: p.S216N .
OE33 SNV: p.E316A; p.H2567N .
ONS76 SNV: p.L3014I DBIA    Probe Info 
OVCAR8 SNV: p.D742Y .
OVTOKO SNV: p.P3030L .
PC9 SNV: p.L1539V .
PF382 SNV: p.S2038G .
RKO SNV: p.V2568A .
RPMI7951 SNV: p.G2183E .
RVH421 SNV: p.G3141E .
SH4 SNV: p.S1885F .
SHP77 Deletion: p.G877AfsTer4 .
SKMEL24 SNV: p.N920K .
SKMEL28 SNV: p.G2635R .
SKMEL30 SNV: p.A590T; p.V1936M .
SNU449 SNV: p.S579R .
SW1573 SNV: p.Q1441H .
SW480 SNV: p.G1992V .
SW620 SNV: p.G1992V .
SW948 SNV: p.D1262Y; p.S2657F .
TF1 SNV: p.I63M .
WM115 SNV: p.P1624S .
WM2664 SNV: p.P1624S .
WM793 SNV: p.S1654F .
YSCCC SNV: p.D810Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C3181(2.16)  LDD3376  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 D283 Med C3181(1.74)  LDD2312  [1]
 LDCM0023  KB03 Daoy C3181(2.08)  LDD2731  [1]
 LDCM0024  KB05 ONS-76 C3181(2.16)  LDD3376  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840