Details of the Target

General Information of Target

Target ID LDTP10692
Target Name Guanylate-binding protein 4 (GBP4)
Gene Name GBP4
Gene ID 115361
Synonyms
Guanylate-binding protein 4; EC 3.6.5.-; GTP-binding protein 4; GBP-4; Guanine nucleotide-binding protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL
LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL
RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA
HQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVN
AISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER
EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAV
KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL
TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQ
QKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL
Target Bioclass
Enzyme
Family
TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3 GTPase family, GB1 subfamily
Subcellular location
Golgi apparatus membrane
Function
Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor.
Uniprot ID
Q96PP9
Ensemble ID
ENST00000355754.7
HGNC ID
HGNC:20480

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C284(2.25)  LDD3323  [1]
IA-alkyne
 Probe Info  		C172(0.00); C374(0.00)  LDD0167  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2058 C421(2.29)  LDD2253  [1]
 LDCM0023  KB03 A2058 C421(2.78)  LDD2670  [1]
 LDCM0024  KB05 SKMEL24 C284(2.25)  LDD3323  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanylate-binding protein 1 (GBP1) GB1/RHD3 GTPase family P32455
Guanylate-binding protein 2 (GBP2) GB1/RHD3 GTPase family P32456
Guanylate-binding protein 4 (GBP4) GB1/RHD3 GTPase family Q96PP9
Guanylate-binding protein 5 (GBP5) GB1/RHD3 GTPase family Q96PP8

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060