Details of the Target
General Information of Target
| Target ID | LDTP10655 | |||||
|---|---|---|---|---|---|---|
| Target Name | Collagen alpha-1(XXI) chain (COL21A1) | |||||
| Gene Name | COL21A1 | |||||
| Gene ID | 81578 | |||||
| Synonyms |
COL1AL; Collagen alpha-1(XXI) chain |
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| 3D Structure | ||||||
| Sequence |
MLLWLLLLILTPGREQSGVAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYH
DEKLLKIKHDKIQITEPGNYQCKTRGSSLSDAVHVEFSPDWLILQALHPVFEGDNVILRC QGKDNKNTHQKVYYKDGKQLPNSYNLEKITVNSVSRDNSKYHCTAYRKFYILDIEVTSKP LNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGLGWS RSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTGGQLI EGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGRYYCAA DNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILYRFYHE DVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSRPVLTL RAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLTTEHSG NYSCEADNGLGAQHSKVVTLNVTGTSRNRTGLTAAGITGLVLSILVLAAAAALLHYARAR RKPGGLSATGTSSHSPSECQEPSSSRPSRIDPQEPTHSKPLAPMELEPMYSNVNPGDSNP IYSQIWSIQHTKENSANCPMMHQEHEELTVLYSELKKTHPDDSAGEASSRGRAHEEDDEE NYENVPRVLLASDH |
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| Target Bioclass |
Other
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| Family |
Fibril-associated collagens with interrupted helices (FACIT) family
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| Subcellular location |
Secreted, extracellular space, extracellular matrix
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| A2780 | SNV: p.G557E | . | |||
| A431 | SNV: p.R299T | . | |||
| A549 | SNV: p.D757Y | . | |||
| CALU1 | Deletion: p.R745EfsTer15 | . | |||
| CAOV3 | SNV: p.C430Y | . | |||
| CCK81 | SNV: p.G907D | . | |||
| COLO792 | SNV: p.K185R | . | |||
| G361 | SNV: p.D43N | . | |||
| HCT116 | SNV: p.P894T | . | |||
| HCT15 | SNV: p.S19Y | . | |||
| HS936T | SNV: p.G695E | . | |||
| HT115 | SNV: p.S250P | . | |||
| IGR39 | SNV: p.N66K | . | |||
| JURLMK1 | SNV: p.Q929P | . | |||
| KATOIII | SNV: p.G256R | . | |||
| LOXIMVI | SNV: p.S822F | . | |||
| MEWO | SNV: p.D949N | . | |||
| NCIH23 | SNV: p.T36A | . | |||
| NCIH661 | Substitution: p.P583S | . | |||
| SKMEL3 | SNV: p.G656E | . | |||
| SNU5 | SNV: p.S215Y | . | |||
| SW403 | SNV: p.P742H | . | |||
| SW480 | SNV: p.E898Ter | . | |||
| TC71 | SNV: p.S591Y | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
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C797(2.60) | LDD3318 | [1] | |
Competitor(s) Related to This Target