Details of the Target

General Information of Target

Target ID LDTP10615
Target Name Zinc finger protein 641 (ZNF641)
Gene Name ZNF641
Gene ID 121274
Synonyms
Zinc finger protein 641
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSLQALCSGLPLRPLPENRGRQAGVPHAPVRTPSLSPVEKQLALRNALRYFPPDVQELL
APEFAQELQLYGHIYMYRFCPDIEMRAYPIEQYPCQTKVAAAIMHMIMNNLDPAVAQFPQ
ELVTYGGNGQVFSNWAQFWLTMFYLSKMTEEQTLVMYSGHPLGLFPSSRSAPRLVITNGM
VIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAARRYLGIEDLA
GKVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDKAALEKRHRQGWLMEVTDSLDRCIQRL
REARKKKEVLSLGYHGNVVALWERLVHELDTTGECLVDLGSDQTSCHNPFNGGYYPVQLS
FTEAQSLMASNPAVFKDLVQESLRRQVSAINRLAEEKFFFWDYGNAFLLEAQRAGADVEK
KGAGRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDELATSVLEEAIADGV
KVSVKLQYMDNIRWIREAARHRLVVGSQARILYSDQKGRVAIAVAINQAIACRRIKAPVV
LSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEV
INGGFGLVLDGTPEAEGRARLMLSWDVSNGVARRCWSGNQKAYEIICQTMQENSTLVVTL
PHKVEDERVLQQALQL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Transcriptional activator. Activates transcriptional activities of SRE and AP-1.
Uniprot ID
Q96N77
Ensemble ID
ENST00000301042.7
HGNC ID
HGNC:31834

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C331(0.92)  LDD1492  [1]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C331(1.22)  LDD1508  [1]
 LDCM0277  AC18 HEK-293T C331(1.08)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C331(1.06)  LDD1518  [1]
 LDCM0286  AC26 HEK-293T C331(1.21)  LDD1525  [1]
 LDCM0295  AC34 HEK-293T C331(1.13)  LDD1534  [1]
 LDCM0304  AC42 HEK-293T C331(1.47)  LDD1543  [1]
 LDCM0313  AC50 HEK-293T C331(1.10)  LDD1552  [1]
 LDCM0321  AC58 HEK-293T C331(1.01)  LDD1560  [1]
 LDCM0367  CL1 HEK-293T C331(0.90)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C331(1.06)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C331(1.08)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C331(1.03)  LDD1582  [1]
 LDCM0383  CL113 HEK-293T C331(1.11)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C331(1.11)  LDD1591  [1]
 LDCM0392  CL121 HEK-293T C331(1.13)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C331(1.01)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C331(1.01)  LDD1604  [1]
 LDCM0405  CL18 HEK-293T C331(1.08)  LDD1609  [1]
 LDCM0413  CL25 HEK-293T C331(0.87)  LDD1617  [1]
 LDCM0419  CL30 HEK-293T C331(1.17)  LDD1623  [1]
 LDCM0426  CL37 HEK-293T C331(1.04)  LDD1630  [1]
 LDCM0432  CL42 HEK-293T C331(1.02)  LDD1636  [1]
 LDCM0439  CL49 HEK-293T C331(0.86)  LDD1643  [1]
 LDCM0445  CL54 HEK-293T C331(1.11)  LDD1648  [1]
 LDCM0451  CL6 HEK-293T C331(0.91)  LDD1654  [1]
 LDCM0453  CL61 HEK-293T C331(0.95)  LDD1656  [1]
 LDCM0458  CL66 HEK-293T C331(1.23)  LDD1661  [1]
 LDCM0466  CL73 HEK-293T C331(1.01)  LDD1669  [1]
 LDCM0471  CL78 HEK-293T C331(1.07)  LDD1674  [1]
 LDCM0479  CL85 HEK-293T C331(0.92)  LDD1682  [1]
 LDCM0485  CL90 HEK-293T C331(0.92)  LDD1688  [1]
 LDCM0492  CL97 HEK-293T C331(0.96)  LDD1695  [1]
 LDCM0022  KB02 HEK-293T C331(0.92)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C331(0.95)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C331(0.98)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
T-complex protein 1 subunit epsilon (CCT5) TCP-1 chaperonin family P48643
Rhombotin-1 (LMO1) . P25800
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004