Details of the Target
General Information of Target
| Target ID | LDTP10607 | |||||
|---|---|---|---|---|---|---|
| Target Name | Janus kinase and microtubule-interacting protein 1 (JAKMIP1) | |||||
| Gene Name | JAKMIP1 | |||||
| Gene ID | 152789 | |||||
| Synonyms |
GABABRBP; JAMIP1; MARLIN1; Janus kinase and microtubule-interacting protein 1; GABA-B receptor-binding protein; Multiple alpha-helices and RNA-linker protein 1; Marlin-1 |
|||||
| 3D Structure | ||||||
| Sequence |
MTVGRPEGAPGGAEGSRQIFPPESFADTEAGEELSGDGLVLPRASKLDEFLSPEEEIDST
SDSTGSIYQNLQELKQKGRWCLLESLFQSDPESDENLSEDEEDLESFFQDKDRGMVQVQC PQALRCGSTRRCSSLNNLPSNIPRPQTQPPSGSRPPSQHRSVSSWASSITVPRPFRMTLR EARKKAEWLGSPASFEQERQRAQRQGEEEAECHRQFRAQPVPAHVYLPLYQEIMERSEAR RQAGIQKRKELLLSSLKPFSFLEKEEQLKEAARQRDLAATAEAKISKQKATRRIPKSILE PALGDKLQEAELFRKIRIQMRALDMLQMASSPIASSSNRANPQPRTATRTQQEKLGFLHT NFRFQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPFLLRTANLRHPQRPCDAATT GRRQDSPQPPATPLPRSRSLSGLASLSANTLPVHITDATRKRESAVRSALEKKNKADESI QWLEIHKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKELEEMK QRIQTRPYLFEQVAKDLAKKEAEQWYLDTLKQAGLEEDFVRNKGQGTRAVQEKETKIKDF PRFQETTKLSIRDPEQGLEGSLEQPASPRKVLEELSHQSPENLVSLA |
|||||
| Target Bioclass |
Other
|
|||||
| Family |
JAKMIP family
|
|||||
| Subcellular location |
Cytoplasm, cytoskeleton
|
|||||
| Function | Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K261(6.25) | LDD0277 | [1] | |
|
DBIA Probe Info |
 |
C489(3.57) | LDD3420 | [2] | |
Competitor(s) Related to This Target
References