Details of the Target
General Information of Target
| Target ID | LDTP10586 | |||||
|---|---|---|---|---|---|---|
| Target Name | Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1) | |||||
| Gene Name | PCMTD1 | |||||
| Gene ID | 115294 | |||||
| Synonyms |
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 |
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| 3D Structure | ||||||
| Sequence |
MLQKPRNRGRSGGQAERDRDWSHSGNPGASRAGEDARVLRDGFAEEAPSTSRGPGGSQGS
QGPSPQGARRAQAAPAVGPRSQKQLELKVSELVQFLLIKDQKKIPIKRADILKHVIGDYK DIFPDLFKRAAERLQYVFGYKLVELEPKSNTYILINTLEPVEEDAEMRGDQGTPTTGLLM IVLGLIFMKGNTIKETEAWDFLRRLGVYPTKKHLIFGDPKKLITEDFVRQRYLEYRRIPH TDPVDYEFQWGPRTNLETSKMKVLKFVAKVHNQDPKDWPAQYCEALADEENRARPQPSGP APSS |
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| Target Bioclass |
Enzyme
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| Family |
Methyltransferase superfamily, L-isoaspartyl/D-aspartyl protein methyltransferase family
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| Subcellular location |
Cytoplasm
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| Function |
Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity. May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C43(2.48) | LDD3316 | [1] | |
Competitor(s) Related to This Target