Details of the Target

General Information of Target

Target ID LDTP10570
Target Name Tektin-5 (TEKT5)
Gene Name TEKT5
Gene ID 146279
Synonyms
Tektin-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEELLPDGQIWANMDPEERMLAAATAFTHICAGQGEGDVRREAQSIQYDPYSKASVAPGK
RPALPVQLQYPHVESNVPSETVSEASQRLRKPVMKRKVLRRKPDGEVLVTDESIISESES
GTENDQDLWDLRQRLMNVQFQEDKESSFDVSQKFNLPHEYQGISQDQLICSLQREGMGSP
AYEQDLIVASRPKSFILPKLDQLSRNRGKTDRVARYFEYKRDWDSIRLPGEDHRKELRWG
VREQMLCRAEPQSKPQHIYVPNNYLVPTEKKRSALRWGVRCDLANGVIPRKLPFPLSPS
Target Bioclass
Other
Family
Tektin family
Subcellular location
Cell projection, cilium, flagellum
Function May be a structural component of the sperm flagellum.
Uniprot ID
Q96M29
Ensemble ID
ENST00000283025.7
HGNC ID
HGNC:26554

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C462(2.48)  LDD3345  [1]
CY-1
 Probe Info  		N.A.  LDD0246  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AGS C462(2.05)  LDD2263  [1]
 LDCM0023  KB03 AGS C462(1.69)  LDD2680  [1]
 LDCM0024  KB05 NCI-H1650 C462(2.48)  LDD3345  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial (CSKMT) Methyltransferase superfamily A8MUP2
Proteasome subunit beta type-4 (PSMB4) Peptidase T1B family P28070
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid scramblase 4 (PLSCR4) Phospholipid scramblase family Q9NRQ2
Transcription factor
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B6 (HOXB6) Antp homeobox family P17509
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Homeobox protein prophet of Pit-1 (PROP1) Paired homeobox family O75360
Pituitary homeobox 1 (PITX1) Paired homeobox family P78337
Forkhead box protein H1 (FOXH1) . O75593
Homeobox protein VENTX (VENTX) . O95231
T-box transcription factor TBX15 (TBX15) . Q96SF7
T-cell leukemia homeobox protein 3 (TLX3) . O43711
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Keratin-associated protein 12-4 (KRTAP12-4) KRTAP type 12 family P60329
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Calcium-binding protein 2 (CABP2) . Q9NPB3
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Kelch-like protein 38 (KLHL38) . Q2WGJ6
Mitogen-activated protein kinase-binding protein 1 (MAPKBP1) . O60336
Sperm-associated microtubule inner protein 4 (SPMIP4) . Q8N865
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.