Details of the Target

General Information of Target

Target ID LDTP10545
Target Name Bcl-2-modifying factor (BMF)
Gene Name BMF
Gene ID 90427
Synonyms
Bcl-2-modifying factor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLPLLLSSLLGGSQAMDGRFWIRVQESVMVPEGLCISVPCSFSYPRQDWTGSTPAYGYW
FKAVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRV
ERGSYVRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSW
TGAALSSQGTKPTTSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRD
LVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHP
WGPRPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLE
NLGNGTSLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHE
GEFTCHARHPLGSQHVSLSLSVHYSPKLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGE
ELLEGNSSQDSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCEAWNVHGAQSGSILQLPDK
KGLISTAFSNGAFLGIGITALLFLCLALIIMKILPKRRTQTETPRPRFSRHSTILDYINV
VPTAGPLAQKRNQKATPNSPRTPLPPGAPSPESKKNQKKQYQLPSFPEPKSSTQAPESQE
SQEELHYATLNFPGVRPRPEARMPKGTQADYAEVKFQ
Target Bioclass
Other
Family
Bcl-2 family
Function May play a role in apoptosis. Isoform 1 seems to be the main initiator.
Uniprot ID
Q96LC9
Ensemble ID
ENST00000354670.9
HGNC ID
HGNC:24132

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.P3T .
HT115 SNV: p.E176D .
JHH1 SNV: p.A181P .
JURKAT Deletion: p.E122KfsTer51 .
LOXIMVI SNV: p.M1? .
NCIH2170 SNV: p.C139Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C139(2.62)  LDD3377  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 OPM-2 C139(2.30)  LDD2543  [1]
 LDCM0023  KB03 OPM-2 C139(3.12)  LDD2960  [1]
 LDCM0024  KB05 OPM-2 C139(2.62)  LDD3377  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 1 (BCL2L1) Bcl-2 family Q07817
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Peroxisome assembly protein 26 (PEX26) Peroxin-26 family Q7Z412
SEC14-like protein 4 (SEC14L4) . Q9UDX3
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Proto-oncogene c-Rel (REL) . Q04864
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 10 (BCL2L10) Bcl-2 family Q9HD36
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) Bcl-2 family Q07820
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Dynein light chain 1, cytoplasmic (DYNLL1) Dynein light chain family P63167
Dynein light chain 2, cytoplasmic (DYNLL2) Dynein light chain family Q96FJ2
Progranulin (GRN) Granulin family P28799
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4
SHC-transforming protein 3 (SHC3) . Q92529

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004