Details of the Target

General Information of Target

Target ID LDTP10520
Target Name Phosphatase and actin regulator 3 (PHACTR3)
Gene Name PHACTR3
Gene ID 116154
Synonyms
C20orf101; SCAPIN1; Phosphatase and actin regulator 3; Scaffold-associated PP1-inhibiting protein; Scapinin
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAGLLALLGPAGRVGARVRPRATWLLGATAPCAPPPLALALLPPRLDARLLRTARGDCRG
HQDPSQATGTTGSSVSCTEEKKQSKSQQLKKIFQEYGTVGVSLHIGISLISLGIFYMVVS
SGVDMPAILLKLGFKESLVQSKMAAGTSTFVVAYAIHKLFAPVRISITLVSVPLIVRYFR
KVGFFKPPAAKP
Target Bioclass
Enzyme
Family
Phosphatase and actin regulator family
Subcellular location
Nucleus matrix
Uniprot ID
Q96KR7
Ensemble ID
ENST00000355648.8
HGNC ID
HGNC:15833

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.E535Ter .
KASUMI2 SNV: p.P157S .
KYM1 SNV: p.A530V .
KYSE30 SNV: p.V12L .
MEC1 Deletion: p.D215QfsTer80 .
MEWO SNV: p.E118K .
PC14 SNV: p.K110N .
PC9 SNV: p.E432K .
SNGM SNV: p.H298Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C85(1.00)  LDD2361  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Hs 839.T C85(1.00)  LDD2361  [1]
 LDCM0023  KB03 Kelly C85(1.48)  LDD2834  [1]
 LDCM0024  KB05 Kelly C85(1.83)  LDD3251  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840