Details of the Target

General Information of Target

Target ID LDTP10515
Target Name TNFAIP3-interacting protein 3 (TNIP3)
Gene Name TNIP3
Gene ID 79931
Synonyms
ABIN3; LIND; TNFAIP3-interacting protein 3; A20-binding inhibitor of NF-kappa-B activation 3; ABIN-3; Listeria-induced gene protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVE
LVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVE
RDGKLYGRGSTDDKGPVAGWINALEAYQKTGQEIPVNVRFCLEGMEESGSEGLDELIFAR
KDTFFKDVDYVCISDNYWLGKKKPCITYGLRGICYFFIEVECSNKDLHSGVYGGSVHEAM
TDLILLMGSLVDKRGNILIPGINEAVAAVTEEEHKLYDDIDFDIEEFAKDVGAQILLHSH
KKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPNMTPEVVGEQVTSY
LTKKFAELRSPNEFKVYMGHGGKPWVSDFSHPHYLAGRRAMKTVFGVEPDLTREGGSIPV
TLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRYNYIEGTKMLAAYLYEVSQLKD
Target Bioclass
Other
Function
Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
Uniprot ID
Q96KP6
Ensemble ID
ENST00000057513.8
HGNC ID
HGNC:19315

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.K322T .
Ishikawa (Heraklio) 02 ER Deletion: p.N145IfsTer15 .
SNGM SNV: p.L260S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C93(2.37)  LDD3329  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0022  KB02 A498 C93(2.03)  LDD2259  [1]
 LDCM0023  KB03 A498 C93(2.47)  LDD2676  [1]
 LDCM0024  KB05 RAW264.7 C93(2.37)  LDD3329  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) Peptidase C64 family P21580
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
E3 ubiquitin-protein ligase TRIM8 (TRIM8) TRIM/RBCC family Q9BZR9
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCN family member 3 (CCN3) CCN family P48745
Huntingtin (HTT) Huntingtin family P42858
Importin subunit alpha-4 (KPNA3) Importin alpha family O00505
Phospholipid scramblase 3 (PLSCR3) Phospholipid scramblase family Q9NRY6
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Protein FAM161A (FAM161A) FAM161 family Q3B820
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Prelamin-A/C (LMNA) Intermediate filament family P02545
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
DAZ-associated protein 2 (DAZAP2) . Q15038
Melanoma-associated antigen 2 (MAGEA2; MAGEA2B) . P43356
Merlin (NF2) . P35240
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
TNFAIP3-interacting protein 1 (TNIP1) . Q15025

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.