Details of the Target

General Information of Target

Target ID LDTP10511
Target Name X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1)
Gene Name RPGRIP1
Gene ID 57096
Synonyms
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1; RPGR-interacting protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNQLDRITHLNYSELPTGDPSGIEKDELRVGVAYFFSDDEEDLDERGQPDKFGVKAPPG
CTPCPESPSRHHHHLLHQLVLNETQFSAFRGQECIFSKVSGGPQGADLSVYAVTALPALC
EPGDLLELLWLQPAPEPPAPAPHWAVYVGGGQIIHLHQGEIRQDSLYEAGAANVGRVVNS
WYRYRPLVAELVVQNACGHLGLKSEEICWTNSESFAAWCRFGKREFKAGGEVPAGTQPPQ
QQYYLKVHLGENKVHTARFHSLEDLIREKRRIDASGRLRVLQELADLVDDKE
Target Bioclass
Other
Family
RPGRIP1 family
Subcellular location
Cell projection, cilium
Function
May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells.
Uniprot ID
Q96KN7
Ensemble ID
ENST00000382933.8
HGNC ID
HGNC:13436

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.E972G .
AN3CA SNV: p.C665Y .
CCFSTTG1 SNV: p.E320D .
COLO792 SNV: p.G1015E .
HT3 SNV: p.R123Q .
IGROV1 SNV: p.N1198K .
KMRC3 SNV: p.P136S .
LNCaP clone FGC SNV: p.A94E; p.P674S .
MOLT4 SNV: p.R89W .
NCIH2291 SNV: p.R827P .
PF382 SNV: p.Y682C .
SKMEL24 SNV: p.D946N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
1d-yne
 Probe Info  		N.A.  LDD0357  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ribonuclease P protein subunit p25-like protein (RPP25L) Histone-like Alba family Q8N5L8
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Apoptosis-enhancing nuclease (AEN) . Q8WTP8
X-linked retinitis pigmentosa GTPase regulator (RPGR) . Q92834
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hairy/enhancer-of-split related with YRPW motif-like protein (HEYL) HEY family Q9NQ87
Zinc finger protein 337 (ZNF337) Krueppel C2H2-type zinc-finger protein family Q9Y3M9
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 564 (ZNF564) Krueppel C2H2-type zinc-finger protein family Q8TBZ8
Transcriptional repressor p66-beta (GATAD2B) . Q8WXI9
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM74A4/A6 (FAM74A4; FAM74A6) FAM74 family Q5TZK3
Protein fem-1 homolog C (FEM1C) Fem-1 family Q96JP0
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
Nephrocystin-4 (NPHP4) NPHP4 family O75161
Chromobox protein homolog 8 (CBX8) . Q9HC52
Developmental pluripotency-associated protein 4 (DPPA4) . Q7L190
Melanoma-associated antigen B2 (MAGEB2) . O15479
TBC1 domain family member 7 (TBC1D7) . Q9P0N9

References

1 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.