Details of the Target

General Information of Target

Target ID LDTP10510
Target Name Protein LRATD1 (LRATD1)
Gene Name LRATD1
Gene ID 151354
Synonyms
FAM84A; NSE1; Protein LRATD1; LRAT domain-containing 1; Neurologic sensory protein 1; NSE1; Protein FAM84A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAP
IDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEH
KPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDL
GGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSG
GALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHAT
NIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAP
KAKKIKSQHRPTQRFWPNSIAAGVLQQQGGAPGTNPDGSINLDNLQSLSSDSATMAMQQA
MMAAHDDSLDGTEEEDEDEMEEEEEEELEEEVDELQTTNVSDLGLEHSDSLE
Target Bioclass
Other
Family
LRATD family
Subcellular location
Cytoplasm
Function May play a role in cell morphology and motility.
Uniprot ID
Q96KN4
Ensemble ID
ENST00000295092.3
HGNC ID
HGNC:20743

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GAMG SNV: p.A134V .
KASUMI1 SNV: p.V177G; p.V178G .
NCIH3122 SNV: p.V288L .
SNGM Deletion: p.P59RfsTer41 .
SW756 SNV: p.R224G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C197(1.68)  LDD3440  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC108 C197(1.35)  LDD2381  [1]
 LDCM0023  KB03 ICC108 C197(1.60)  LDD2798  [1]
 LDCM0024  KB05 SNU-245 C197(1.68)  LDD3440  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840