Details of the Target

General Information of Target

Target ID LDTP10509
Target Name Homeobox protein PKNOX2 (PKNOX2)
Gene Name PKNOX2
Synonyms
PREP2; Homeobox protein PKNOX2; Homeobox protein PREP-2; PBX/knotted homeobox 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIE
SDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGS
DPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAF
RALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAIT
YGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVV
PLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPG
TKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIA
NIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQ
NEKINRWNYIEGTKLFAAFFLEMAQLH
Target Bioclass
Transcription factor
Family
TALE/MEIS homeobox family
Subcellular location
Nucleus
Uniprot ID
Q96KN3
Ensemble ID
ENST00000298282.14
HGNC ID
HGNC:16714

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.L199P .
HUH1 SNV: p.Q267E .
IGROV1 SNV: p.P349R .
MCC13 SNV: p.P23L .
MFE319 Deletion: p.Y184TfsTer47 .
NALM6 SNV: p.R304C .
NCIH2170 SNV: p.D70E .
NCIH2172 Deletion: p.Q214RfsTer17 .
OZ SNV: p.T457M .
RKO Deletion: p.Y184TfsTer47 .
SUPT1 SNV: p.N290T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C165(5.35)  LDD2230  [1]
DBIA
 Probe Info  		C91(5.60)  LDD3439  [2]
VSF
 Probe Info  		N.A.  LDD0007  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AU565 C91(2.28)  LDD2265  [2]
 LDCM0023  KB03 AU565 C91(3.32)  LDD2682  [2]
 LDCM0024  KB05 SNU-1196 C91(5.60)  LDD3439  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
ATPase PAAT (PAAT) . Q9H8K7
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cAMP-responsive element-binding protein-like 2 (CREBL2) BZIP family O60519
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centromere protein P (CENPP) CENP-P/CTF19 family Q6IPU0
DET1- and DDB1-associated protein 1 (DDA1) DDA1 family Q9BW61
Protein FAM110B (FAM110B) FAM110 family Q8TC76
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
Arfaptin-2 (ARFIP2) . P53365
Cleavage stimulation factor subunit 2 tau variant (CSTF2T) . Q9H0L4
Coiled-coil domain-containing protein 116 (CCDC116) . Q8IYX3
Coiled-coil domain-containing protein 185 (CCDC185) . Q8N715
Cortactin-binding protein 2 (CTTNBP2) . Q8WZ74
CTTNBP2 N-terminal-like protein (CTTNBP2NL) . Q9P2B4
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Four and a half LIM domains protein 2 (FHL2) . Q14192
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Microspherule protein 1 (MCRS1) . Q96EZ8
Nuclear receptor-interacting protein 1 (NRIP1) . P48552
PRKCA-binding protein (PICK1) . Q9NRD5
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) . P46940

References

1 A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes. Nat Protoc. 2020 Sep;15(9):2891-2919. doi: 10.1038/s41596-020-0352-2. Epub 2020 Jul 20.
Mass spectrometry data entry: PXD016048
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764