Details of the Target
General Information of Target
| Target ID | LDTP10475 | |||||
|---|---|---|---|---|---|---|
| Target Name | Zinc finger protein 462 (ZNF462) | |||||
| Gene Name | ZNF462 | |||||
| Gene ID | 58499 | |||||
| Synonyms |
KIAA1803; Zinc finger protein 462; Zinc finger PBX1-interacting protein; ZFPIP |
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| 3D Structure | ||||||
| Sequence |
MESVTFEDVAVEFIQEWALLDSARRSLCKYRMLDQCRTLASRGTPPCKPSCVSQLGQRAE
PKATERGILRATGVAWESQLKPEELPSMQDLLEEASSRDMQMGPGLFLRMQLVPSIEERE TPLTREDRPALQEPPWSLGCTGLKAAMQIQRVVIPVPTLGHRNPWVARDSAVPARDPAWL QEDKVEEEAMAPGLPTACSQEPVTFADVAVVFTPEEWVFLDSTQRSLYRDVMLENYRNLA SVADQLCKPNALSYLEERGEQWTTDRGVLSDTCAEPQCQPQEAIPSQDTFTEILSIDVKG EQPQPGEKLYKYNELEKPFNSIEPLFQYQRIHAGEASCECQEIRNSFFQSAHLIVPEKIR SGDKSYACNKCEKSFRYSSDLIRHEKTHTAEKCFDCQECGQAFKYSSNLRRHMRTHTGEK PFECSQCGKTFTRNFNLILHQRNHTGEKPYECKDCGKAFNQPSSLRSHVRTHTGEKPFEC SQCGKAFREHSSLKTHLRTHTREKPYECNQCGKPFRTSTHLNVHKRIHTGEKLYECATCG QVLSRLSTLKSHMRTHTGEKPYVCQECGRAFSEPSSLRKHARTHSGKKPYACQECGRAFG QSSHLIVHVRTHSAGRPYQCNQCEKAFRHSSSLTVHKRTHVGRETIRNGSLPLSMSHPYC GPLAN |
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| Target Bioclass |
Transcription factor
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| Subcellular location |
Nucleus
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| Function |
Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA. Regulates neuronal development and neural cell differentiation.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| 8505C | SNV: p.D1238Y | DBIA Probe Info | |||
| A2058 | Deletion: p.H572_P576del | DBIA Probe Info | |||
| A549 | SNV: p.Q759H | DBIA Probe Info | |||
| AN3CA | Deletion: p.Q109NfsTer16 SNV: p.E2249D |
DBIA Probe Info | |||
| BICR22 | SNV: p.D1447H | DBIA Probe Info | |||
| CAL51 | SNV: p.N2500D | . | |||
| COLO678 | SNV: p.R452H | DBIA Probe Info | |||
| COLO792 | SNV: p.P536L | DBIA Probe Info | |||
| EFO27 | SNV: p.T2183S | . | |||
| GB1 | SNV: p.N358D | DBIA Probe Info | |||
| HCT116 | SNV: p.S1630F; p.P1707R | . | |||
| HCT15 | SNV: p.R1734M; p.A2017V; p.R2114M | . | |||
| IGR37 | SNV: p.P1244S | DBIA Probe Info | |||
| IGR39 | SNV: p.P1244S | DBIA Probe Info | |||
| IGROV1 | SNV: p.P1001S | DBIA Probe Info | |||
| Ishikawa (Heraklio) 02 ER | SNV: p.M449V; p.K1693E | DBIA Probe Info | |||
| JURKAT | SNV: p.Q1476Ter | . | |||
| KMS11 | SNV: p.R1372G | . | |||
| KYSE30 | SNV: p.D2382N | DBIA Probe Info | |||
| LNCaP clone FGC | SNV: p.E979A | DBIA Probe Info | |||
| NALM6 | SNV: p.A1346T | . | |||
| NCIH1155 | SNV: p.R856W | . | |||
| NCIH2172 | SNV: p.Q558L; p.G1311R | . | |||
| OVK18 | SNV: p.A1500T | DBIA Probe Info | |||
| PC3 | SNV: p.P103L | . | |||
| PC9 | SNV: p.E1636K | . | |||
| REH | SNV: p.R2280H | . | |||
| RKO | SNV: p.T1525A | DBIA Probe Info | |||
| SNGM | SNV: p.V1991A | DBIA Probe Info | |||
| SNU5 | SNV: p.Q2185K | . | |||
| SUPT1 | SNV: p.R255Ter; p.V1999M | DBIA Probe Info | |||
| SW1783 | SNV: p.S1432R | DBIA Probe Info | |||
| SW620 | SNV: p.S2129F | DBIA Probe Info | |||
| SW756 | SNV: p.S2096T | . | |||
| TE11 | SNV: p.E246K | DBIA Probe Info | |||
| ZR751 | SNV: p.D686Y | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
ONAyne Probe Info |
 |
K179(2.48) | LDD0274 | [1] | |
|
DBIA Probe Info |
 |
C930(1.65); C574(2.53) | LDD3310 | [2] | |
|
IPM Probe Info |
 |
C2287(2.00) | LDD1701 | [3] | |
|
IA-alkyne Probe Info |
 |
C1984(0.00); C1729(0.00) | LDD0165 | [4] | |
|
NAIA_4 Probe Info |
 |
N.A. | LDD2226 | [5] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References