Details of the Target

General Information of Target

Target ID LDTP10459
Target Name 1,5-anhydro-D-fructose reductase (AKR1E2)
Gene Name AKR1E2
Gene ID 83592
Synonyms
AKR1CL2; AKRDC1; 1,5-anhydro-D-fructose reductase; AF reductase; EC 1.1.1.263; Aldo-keto reductase family 1 member C-like protein 2; Aldo-keto reductase family 1 member E2; LoopADR; Testis aldo-keto reductase; htAKR; Testis-specific protein; hTSP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGTANPLLDREEHCLRLGESFEKRPRASFHTIRYDFKPASIDTSCEGELQVGKGDEVTI
TLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKLSSSIQVKKTRAEGSSKIQ
ARMEQQPTRPPQTSQPPPPPPPMPFRAPTKPPVGPKTSPLKDNPSPEPQLDDIKRELRAE
VDIIEQMSSSSGSSSSDSESSSGSDDDSSSSGGEDNGPASPPQPSHQQPYNSRPAVANGT
SRPQGSNQLMNTLRNDLQLSESGSDSDD
Target Bioclass
Enzyme
Family
Aldo/keto reductase family
Subcellular location
Cytoplasm
Function Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro).
Uniprot ID
Q96JD6
Ensemble ID
ENST00000298375.12
HGNC ID
HGNC:23437

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 SNV: p.M155L .
CCK81 Deletion: p.P249del .
KMCH1 SNV: p.D132V .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		1.08  LDD0137  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lumateperone Small molecular drug DB06077

References

1 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.