Details of the Target
General Information of Target
| Target ID | LDTP10451 | |||||
|---|---|---|---|---|---|---|
| Target Name | Dynein axonemal heavy chain 8 (DNAH8) | |||||
| Gene Name | DNAH8 | |||||
| Gene ID | 1769 | |||||
| Synonyms |
Dynein axonemal heavy chain 8; Axonemal beta dynein heavy chain 8; Ciliary dynein heavy chain 8 |
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| 3D Structure | ||||||
| Sequence |
MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTR
MDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSEL RLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSE LLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEILMKNK NSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCSPECL WEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMD LVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLT EVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTVKEGDHQKE AFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV |
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| Target Bioclass |
Other
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| Family |
Dynein heavy chain family
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| Subcellular location |
Cytoplasm, cytoskeleton, flagellum axoneme
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| Function |
Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K3731(4.95) | LDD0277 | [1] | |
|
ATP probe Probe Info |
 |
N.A. | LDD0199 | [2] | |
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YN-1 Probe Info |
 |
N.A. | LDD0447 | [3] | |
References