Details of the Target
General Information of Target
| Target ID | LDTP10434 | |||||
|---|---|---|---|---|---|---|
| Target Name | Carboxypeptidase B2 (CPB2) | |||||
| Gene Name | CPB2 | |||||
| Gene ID | 1361 | |||||
| Synonyms |
Carboxypeptidase B2; EC 3.4.17.20; Carboxypeptidase U; CPU; Plasma carboxypeptidase B; pCPB; Thrombin-activable fibrinolysis inhibitor; TAFI |
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| 3D Structure | ||||||
| Sequence |
MAGSPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKL
GDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIV DIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETV AKEISEAMKSLPALIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIE TTPTETASRKTSDMVLKRKQTKDCPQRKWYPLRPKKINLDT |
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| Target Type |
Clinical trial
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| Target Bioclass |
Enzyme
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| Family |
Peptidase M14 family
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| Subcellular location |
Secreted
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| Function |
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
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| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
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| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C250(2.53) | LDD2351 | [1] | |
Competitor(s) Related to This Target