Details of the Target

General Information of Target

Target ID LDTP10401
Target Name Small G protein signaling modulator 3 (SGSM3)
Gene Name SGSM3
Gene ID 27352
Synonyms
MAP; RABGAPLP; RUTBC3; Small G protein signaling modulator 3; Merlin-associated protein; RUN and TBC1 domain-containing protein 3; Rab-GTPase-activating protein-like protein; RabGAPLP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPLDIDEVEAPEEVEVLEPEEDFEQFLLPVINEMREDIASLIREHGRAYLRTRSKLWEM
DNMLIQIKTQVEASEESALNHVQHPSGEADERVSELCEKAEEKAKEIAKMAEMLVELVWR
IERSESS
Target Bioclass
Transporter and channel
Family
Small G protein signaling modulator family
Subcellular location
Cytoplasm
Function May play a cooperative role in NF2-mediated growth suppression of cells.
Uniprot ID
Q96HU1
Ensemble ID
ENST00000248929.14
HGNC ID
HGNC:25228

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S238N .
HCT15 SNV: p.A113V .
HLF SNV: p.R618K .
Ishikawa (Heraklio) 02 ER Deletion: p.A387PfsTer72 .
MCC13 Substitution: p.A387V .
MCC26 SNV: p.E143Q .
MOLT4 SNV: p.T166S; p.Q381H .
NCIH1155 SNV: p.F617S .
NCIH358 SNV: p.F285C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C505(2.54); C593(3.59)  LDD3369  [1]
NAIA_5
 Probe Info  		C477(0.00); C9(0.00)  LDD2224  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C9(1.17); C477(0.91)  LDD2227  [2]
 LDCM0022  KB02 AU565 C545(2.27); C593(3.48)  LDD2265  [1]
 LDCM0023  KB03 AU565 C545(3.81); C593(9.10)  LDD2682  [1]
 LDCM0024  KB05 OAW-42 C505(2.54); C593(3.59)  LDD3369  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Flavin-containing monooxygenase 3 (FMO3) FMO family P31513

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019