Details of the Target

General Information of Target

Target ID LDTP10390
Target Name GRAM domain-containing protein 2B (GRAMD2B)
Gene Name GRAMD2B
Gene ID 65983
Synonyms
GRAMD3; NS3TP2; GRAM domain-containing protein 2B; HCV NS3-transactivated protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTDLNDNICKRYIKMITNIVILSLIICISLAFWIISMTASTYYGNLRPISPWRWLFSVVV
PVLIVSNGLKKKSLDHSGALGGLVVGFILTIANFSFFTSLLMFFLSSSKLTKWKGEVKKR
LDSEYKEGGQRNWVQVFCNGAVPTELALLYMIENGPGEIPVDFSKQYSASWMCLSLLAAL
ACSAGDTWASEVGPVLSKSSPRLITTWEKVPVGTNGGVTVVGLVSSLLGGTFVGIAYFLT
QLIFVNDLDISAPQWPIIAFGGLAGLLGSIVDSYLGATMQYTGLDESTGMVVNSPTNKAR
HIAGKPILDNNAVNLFSSVLIALLLPTAAWGFWPRG
Target Bioclass
Other
Uniprot ID
Q96HH9
Ensemble ID
ENST00000285689.8
HGNC ID
HGNC:24911

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT3 SNV: p.P228A .
L428 SNV: p.K39N .
NCIH1155 SNV: p.Q5R .
RKO SNV: p.V312A .
TE1 SNV: p.S22C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C27(3.60)  LDD3323  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Caov-3 C27(2.79)  LDD2295  [1]
 LDCM0023  KB03 Caov-3 C27(4.95); C422(2.26)  LDD2712  [1]
 LDCM0024  KB05 SKMEL24 C27(3.60)  LDD3323  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nicotinate phosphoribosyltransferase (NAPRT) NAPRTase family Q6XQN6
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycodelin (PAEP) Lipocalin family P09466
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Transmembrane protein 43 (TMEM43) TMEM43 family Q9BTV4
C-type lectin domain family 4 member K (CD207) . Q9UJ71
FERM domain-containing protein 8 (FRMD8) . Q9BZ67
GRAM domain-containing protein 2B (GRAMD2B) . Q96HH9
Mortality factor 4-like protein 2 (MORF4L2) . Q15014

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255