Details of the Target

General Information of Target

Target ID LDTP10385
Target Name N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (ACY3)
Gene Name ACY3
Gene ID 91703
Synonyms
ASPA2; N-acyl-aromatic-L-amino acid amidohydrolase; carboxylate-forming; EC 3.5.1.114; Acylase III; Aminoacylase-3; ACY-3; Aspartoacylase-2; Hepatitis C virus core-binding protein 1; HCBP1; HCV core-binding protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPWPPKGLVPAMLWGLSLFLNLPGPIWLQPSPPPQSSPPPQPHPCHTCRGLVDSFNKGL
ERTIRDNFGGGNTAWEEENLSKYKDSETRLVEVLEGVCSKSDFECHRLLELSEELVESWW
FHKQQEAPDLFQWLCSDSLKLCCPAGTFGPSCLPCPGGTERPCGGYGQCEGEGTRGGSGH
CDCQAGYGGEACGQCGLGYFEAERNASHLVCSACFGPCARCSGPEESNCLQCKKGWALHH
LKCVDIDECGTEGANCGADQFCVNTEGSYECRDCAKACLGCMGAGPGRCKKCSPGYQQVG
SKCLDVDECETEVCPGENKQCENTEGGYRCICAEGYKQMEGICVKEQIPESAGFFSEMTE
DELVVLQQMFFGIIICALATLAAKGDLVFTAIFIGAVAAMTGYWLSERSDRVLEGFIKGR
Target Bioclass
Enzyme
Family
AspA/AstE family, Aspartoacylase subfamily
Subcellular location
Apical cell membrane
Function Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids.
Uniprot ID
Q96HD9
Ensemble ID
ENST00000255082.8
HGNC ID
HGNC:24104

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C61(1.50)  LDD3370  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 K052 C61(1.51)  LDD2427  [1]
 LDCM0023  KB03 K052 C61(1.50)  LDD2844  [1]
 LDCM0024  KB05 OCI-AML-2 C61(1.50)  LDD3370  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840