Details of the Target

General Information of Target

Target ID LDTP10352
Target Name Phospholipid phosphatase-related protein type 2 (PLPPR2)
Gene Name PLPPR2
Gene ID 64748
Synonyms
LPPR2; PRG4; Phospholipid phosphatase-related protein type 2; Inactive phospholipid phosphatase PLPPR2; Lipid phosphate phosphatase-related protein type 2; Plasticity-related gene 4 protein; PRG-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKSGTEVADEEEEREHDLPTHPRGP
TCNACSSQALDGRGSLAPLTSEPCSQPCGVAASHCTTCSPYSSPFYIRTADMVPNGGGGE
RLSFAPTYYKEGGPPSLKLAAPQSYPVTWPGSGREAFTNPRAISTDV
Target Bioclass
Enzyme
Family
PA-phosphatase related phosphoesterase family
Subcellular location
Membrane
Uniprot ID
Q96GM1
Ensemble ID
ENST00000251473.9
HGNC ID
HGNC:29566

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C191(2.14)  LDD3369  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 MCAS C191(1.50)  LDD2449  [1]
 LDCM0023  KB03 IGR-39 C191(4.06)  LDD2814  [1]
 LDCM0024  KB05 OAW-42 C191(2.14)  LDD3369  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) Ubiquitin-conjugating enzyme family Q9Y385
E3 ubiquitin-protein ligase MARCHF2 (MARCHF2) . Q9P0N8
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Claudin-5 (CLDN5) Claudin family O00501
Transmembrane emp24 domain-containing protein 9 (TMED9) EMP24/GP25L family Q9BVK6
Thiamine transporter 2 (SLC19A3) Reduced folate carrier (RFC) transporter (TC 2.A.48) family Q9BZV2
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Immunoglobulin
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Sialic acid-binding Ig-like lectin 12 (SIGLEC12) SIGLEC (sialic acid binding Ig-like lectin) family Q96PQ1
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR) . Q9H7M9
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Claudin-9 (CLDN9) Claudin family O95484
Glycophorin-C (GYPC) Glycophorin-C family P04921
Cytosolic iron-sulfur assembly component 2A (CIAO2A) MIP18 family Q9H5X1
Small cell adhesion glycoprotein (SMAGP) SMAGP family Q0VAQ4
Syntaxin-12 (STX12) Syntaxin family Q86Y82
Ly6/PLAUR domain-containing protein 5 (LYPD5) . Q6UWN5
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019