Details of the Target

General Information of Target

Target ID LDTP10333
Target Name Kelch domain-containing protein 7B (KLHDC7B)
Gene Name KLHDC7B
Gene ID 113730
Synonyms
Kelch domain-containing protein 7B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAQRLISNRTSQQSASNSDYTWEYEYYEIGPVSFEGLKAHKYSIVIGFWVGLAVFVIFM
FFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGRPLEPDKVFSRQGNEESRSLFHCYI
NEVERLDRAKACHQTTALDSDVQLQEAIRSSGQPEEELNRLMKFDIPNFVNTDQNYFGED
DLLISEPPIVLETKPLSQTSHKDLD
Target Bioclass
Other
Uniprot ID
Q96G42
Ensemble ID
ENST00000395676.4
HGNC ID
HGNC:25145

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C448(3.05); C258(4.51)  LDD3444  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCC1187 C448(3.07); C258(4.70)  LDD2337  [1]
 LDCM0023  KB03 HCC1187 C448(4.25); C258(9.75)  LDD2754  [1]
 LDCM0024  KB05 SNU-478 C448(3.05); C258(4.51)  LDD3444  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840