Details of the Target

General Information of Target

Target ID LDTP10303
Target Name Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1)
Gene Name PIK3IP1
Gene ID 113791
Synonyms
HGFL; Phosphoinositide-3-kinase-interacting protein 1; PI3K-interacting protein 1; Kringle domain-containing protein HGFL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK
RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN
LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV
YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR
LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS
TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN
LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT
CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG
TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE
ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR
KSDAGISSADAPRKFNMKMI
Target Bioclass
Enzyme
Subcellular location
Cell membrane
Function Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
Uniprot ID
Q96FE7
Ensemble ID
ENST00000215912.10
HGNC ID
HGNC:24942

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.M213I .
SUPT1 Insertion: p.Y20GfsTer133 .
TE10 SNV: p.S193F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C71(2.92)  LDD3312  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C71(1.00)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C71(1.32)  LDD2660  [1]
 LDCM0024  KB05 HMCB C71(2.92)  LDD3312  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840