Details of the Target

General Information of Target

Target ID LDTP10298
Target Name CB1 cannabinoid receptor-interacting protein 1 (CNRIP1)
Gene Name CNRIP1
Gene ID 25927
Synonyms
C2orf32; CB1 cannabinoid receptor-interacting protein 1; CRIP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMSNGNNDFVVLSNSSIATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPNGCLQLNG
TVKSSFLPLDNQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPH
SEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQPVQQHIANIRPSRPFKLPKS
YAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNM
VKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRY
SRVVFTSSGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAI
LNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDMAARRKDQLKCTNVPRKCTK
YNAVYQILHYLVDKDFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDG
VTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLI
VSYFLYRVVFHFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSIT
LQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHE
RYLLNIFTCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYL
WLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHG
EELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFF
YQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERS
TGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPE
GLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTI
FVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVG
SAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTC
GQIPLPKKLQCSAFSHALSTSPSDKGQSKTHTINAYHLDPRGPKSELEHEFYELEPLASH
SCTAPEKTTYEETHICSEFFNSQAKNLGMPVHAAYNSELSKSTESDAGSALLQPPLEQHT
VCHFFSLNQRCSCPDAYKHLNYGPHSCQQMGDCLCHQCSPTTSSFVQIQNGVAPLKATHQ
AVEGFVHPITHIHHCPCLQGRVKPAGMQNSLPRNFFLHPVQHIQAQEKIGKTNVHSLQRS
IEEHLPKMAEPSSFVCRSTGSLLKTCCDPENKQRELCKNRDVSNLESSGGTENKAGGKVE
LSLSQTDASVNSEHFNQNEPKVLFNHLMGEAGCRSCPNNSQSCGRIVRVKCNSVDCQMPN
MEANVPAVLTHSELSGESLLIKTL
Target Bioclass
Other
Family
CNRIP family
Function
[Isoform 1]: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.; [Isoform 2]: Does not suppress cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.
Uniprot ID
Q96F85
Ensemble ID
ENST00000263655.4
HGNC ID
HGNC:24546

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.W121Ter .
HUPT4 SNV: p.T119R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K51(6.27)  LDD0277  [1]
DBIA
 Probe Info  		C134(1.20)  LDD1507  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C134(1.20)  LDD1507  [2]
 LDCM0276  AC17 HEK-293T C134(1.31)  LDD1515  [2]
 LDCM0281  AC21 HEK-293T C134(1.05)  LDD1520  [2]
 LDCM0285  AC25 HEK-293T C134(1.28)  LDD1524  [2]
 LDCM0289  AC29 HEK-293T C134(1.35)  LDD1528  [2]
 LDCM0294  AC33 HEK-293T C134(1.09)  LDD1533  [2]
 LDCM0298  AC37 HEK-293T C134(1.38)  LDD1537  [2]
 LDCM0303  AC41 HEK-293T C134(1.20)  LDD1542  [2]
 LDCM0307  AC45 HEK-293T C134(1.32)  LDD1546  [2]
 LDCM0311  AC49 HEK-293T C134(1.32)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C134(1.47)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C134(1.23)  LDD1555  [2]
 LDCM0320  AC57 HEK-293T C134(1.08)  LDD1559  [2]
 LDCM0325  AC61 HEK-293T C134(1.12)  LDD1564  [2]
 LDCM0248  AKOS034007472 HEK-293T C134(1.09)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C134(1.29)  LDD1570  [2]
 LDCM0367  CL1 HEK-293T C134(0.86)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C134(0.98)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C134(1.17)  LDD1575  [2]
 LDCM0374  CL105 HEK-293T C134(1.06)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C134(1.01)  LDD1579  [2]
 LDCM0378  CL109 HEK-293T C134(1.11)  LDD1582  [2]
 LDCM0380  CL110 HEK-293T C134(0.70)  LDD1584  [2]
 LDCM0383  CL113 HEK-293T C134(1.15)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C134(0.82)  LDD1588  [2]
 LDCM0387  CL117 HEK-293T C134(0.90)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C134(0.94)  LDD1592  [2]
 LDCM0392  CL121 HEK-293T C134(0.91)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C134(0.82)  LDD1597  [2]
 LDCM0396  CL125 HEK-293T C134(0.94)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C134(0.77)  LDD1601  [2]
 LDCM0400  CL13 HEK-293T C134(1.01)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C134(1.30)  LDD1605  [2]
 LDCM0404  CL17 HEK-293T C134(1.00)  LDD1608  [2]
 LDCM0407  CL2 HEK-293T C134(0.87)  LDD1611  [2]
 LDCM0409  CL21 HEK-293T C134(1.01)  LDD1613  [2]
 LDCM0413  CL25 HEK-293T C134(0.79)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C134(0.71)  LDD1618  [2]
 LDCM0417  CL29 HEK-293T C134(1.09)  LDD1621  [2]
 LDCM0422  CL33 HEK-293T C134(0.76)  LDD1626  [2]
 LDCM0426  CL37 HEK-293T C134(0.95)  LDD1630  [2]
 LDCM0431  CL41 HEK-293T C134(1.11)  LDD1635  [2]
 LDCM0435  CL45 HEK-293T C134(0.88)  LDD1639  [2]
 LDCM0439  CL49 HEK-293T C134(0.78)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C134(1.22)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C134(0.66)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C134(1.06)  LDD1647  [2]
 LDCM0448  CL57 HEK-293T C134(0.92)  LDD1651  [2]
 LDCM0453  CL61 HEK-293T C134(1.16)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C134(0.68)  LDD1657  [2]
 LDCM0457  CL65 HEK-293T C134(1.24)  LDD1660  [2]
 LDCM0461  CL69 HEK-293T C134(0.85)  LDD1664  [2]
 LDCM0466  CL73 HEK-293T C134(0.85)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C134(0.82)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C134(1.19)  LDD1673  [2]
 LDCM0475  CL81 HEK-293T C134(0.98)  LDD1678  [2]
 LDCM0479  CL85 HEK-293T C134(0.84)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C134(0.80)  LDD1683  [2]
 LDCM0483  CL89 HEK-293T C134(1.04)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C134(1.04)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C134(0.89)  LDD1691  [2]
 LDCM0492  CL97 HEK-293T C134(0.91)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C134(0.73)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C134(0.83)  LDD1631  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402