Details of the Target
General Information of Target
| Target ID | LDTP10234 | |||||
|---|---|---|---|---|---|---|
| Target Name | Ankyrin repeat and SOCS box protein 9 (ASB9) | |||||
| Gene Name | ASB9 | |||||
| Gene ID | 140462 | |||||
| Synonyms |
Ankyrin repeat and SOCS box protein 9; ASB-9 |
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| 3D Structure | ||||||
| Sequence |
MIQNSRPSLLQPQDVGDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQP
SDHGSRRVGMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHP PTALESVMLGVGSRSVAGVCMSPITVIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSG LTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADV IKTHMQLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKM GLKS |
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| Target Bioclass |
Other
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| Family |
Ankyrin SOCS box (ASB) family
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| Subcellular location |
Mitochondrion
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| Function |
Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| DU145 | SNV: p.V147M | DBIA Probe Info | |||
| FTC133 | SNV: p.G198V | . | |||
| HGC27 | SNV: p.A215V | . | |||
| NCIH446 | SNV: p.V128F | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C175(1.22) | LDD3310 | [1] | |
|
NAIA_5 Probe Info |
 |
N.A. | LDD2223 | [2] | |
Competitor(s) Related to This Target
References