Details of the Target

General Information of Target

Target ID LDTP10173
Target Name Collagen triple helix repeat-containing protein 1 (CTHRC1)
Gene Name CTHRC1
Gene ID 115908
Synonyms
Collagen triple helix repeat-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSFEDADTEETVTCLQMTVYHPGQLQCGIFQSISFNREKLPSSEVVKFGRNSNICHYTF
QDKQVSRVQFSLQLFKKFNSSVLSFEIKNMSKKTNLIVDSRELGYLNKMDLPYRCMVRFG
EYQFLMEKEDGESLEFFETQFILSPRSLLQENNWPPHRPIPEYGTYSLCSSQSSSPTEMD
ENES
Target Bioclass
Enzyme
Subcellular location
Secreted, extracellular space, extracellular matrix
Function May act as a negative regulator of collagen matrix deposition.
Uniprot ID
Q96CG8
Ensemble ID
ENST00000330295.10
HGNC ID
HGNC:18831

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.R83W .
HT115 SNV: p.M185I .
K562 SNV: p.A40E .
KNS81FD SNV: p.A212V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.00  LDD0402  [1]
DBIA
 Probe Info  		C55(1.91)  LDD3313  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 13.10  LDD0403  [1]
 LDCM0022  KB02 A204 C55(2.03)  LDD2252  [2]
 LDCM0023  KB03 A204 C55(1.64)  LDD2669  [2]
 LDCM0024  KB05 Hs 936.T C55(1.91)  LDD3313  [2]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840