Details of the Target
General Information of Target
| Target ID | LDTP10151 | |||||
|---|---|---|---|---|---|---|
| Target Name | TBC1 domain family member 20 (TBC1D20) | |||||
| Gene Name | TBC1D20 | |||||
| Gene ID | 128637 | |||||
| Synonyms |
C20orf140; TBC1 domain family member 20 |
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| 3D Structure | ||||||
| Sequence |
MNILPKKSWHVRNKDNVARVRRDEAQAREEEKERERRVLLAQQEARTEFLRKKARHQNSL
PELEAAEAGAPGSGPVDLFRELLEEGKGVIRGNKEYKEEKRQEKERQEKALGILTYLGQS AAEAQTQPPWYQLPPGRGGPPPGPAPDEKIKSRLDPLREMQKHLGKKRQHGGDEGSRSRK EKEGSEKQRPKEPPSLDQLRAERLRREAAERSRAEALLARVQGRALQEGQPEEDETDDRR RRYNSQFNPQLARRPRQQDPHLTH |
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| Target Bioclass |
Other
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| Subcellular location |
Membrane
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| Function |
GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. Involved in maintaining endoplasmic reticulum structure.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
ONAyne Probe Info |
 |
K361(5.88) | LDD0274 | [1] | |
|
AOyne Probe Info |
 |
15.00 | LDD0443 | [2] | |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) | EBP family | Q15125 | |||
Transporter and channel
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Aquaporin-6 (AQP6) | MIP/aquaporin (TC 1.A.8) family | Q13520 | |||
| Transmembrane protein 14B (TMEM14B) | TMEM14 family | Q9NUH8 | |||
Other
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Apolipoprotein C-IV (APOC4) | Apolipoprotein C4 family | P55056 | |||
References