Details of the Target
General Information of Target
| Target ID | LDTP10149 | |||||
|---|---|---|---|---|---|---|
| Target Name | 5'-3' exonuclease PLD4 (PLD4) | |||||
| Gene Name | PLD4 | |||||
| Gene ID | 122618 | |||||
| Synonyms |
C14orf175; 5'-3' exonuclease PLD4; EC 3.1.16.1; Choline phosphatase 4; Phosphatidylcholine-hydrolyzing phospholipase D4; Phospholipase D family member 4; Phospholipase D4; PLD 4 |
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| 3D Structure | ||||||
| Sequence |
MAAACGPGAAGYCLLLGLHLFLLTAGPALGWNDPDRMLLRDVKALTLHYDRYTTSRRLDP
IPQLKCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESS EDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIV VLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGH GATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYP GTWNRAYSPLHGGSGSYSVCSNSDTKTRTASGYGGTRRR |
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| Target Bioclass |
Enzyme
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| Family |
Phospholipase D family
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| Subcellular location |
Endoplasmic reticulum membrane
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| Function |
5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C313(0.89) | LDD3339 | [1] | |
Competitor(s) Related to This Target