Details of the Target

General Information of Target

Target ID LDTP10143
Target Name Uracil phosphoribosyltransferase homolog (UPRT)
Gene Name UPRT
Gene ID 139596
Synonyms
Uracil phosphoribosyltransferase homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSNHQSNYKLSKTEKKFLRKQIKAKHTLLRHEGIETVSYATQSLVVANGGLGNGVSRNQ
LLPVLEKCGLVDALLMPPNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQKITLYLNFV
EKVQWKELRPQALPPGLMVVEEIISSEEEKMLLESVDWTEDTDNQNSQKSLKHRRVKHFG
YEFHYENNNVDKDKPLSGGLPDICESFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHID
THSAFEDEIVSLSLGSEIVMDFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFD
TVQASESLKSGIITSDVGDLTLSKRGLRTSFTFRKVRQTPCNCSYPLVCDSQRKETPPSF
PESDKEASRLEQEYVHQVYEEIAGHFSSTRHTPWPHIVEFLKALPSGSIVADIGCGNGKY
LGINKELYMIGCDRSQNLVDICRERQFQAFVCDALAVPVRSGSCDACISIAVIHHFATAE
RRVAALQEIVRLLRPGGKALIYVWAMEQEYNKQKSKYLRGNRNSQGKKEEMNSDTSVQRS
LVEQMRDMGSRDSASSVPRINDSQEGGCNSRQVSNSKLPVHVNRTSFYSQDVLVPWHLKG
NPDKGKPVEPFGPIGSQDPSPVFHRYYHVFREGELEGACRTVSDVRILQSYYDQGNWCVI
LQKA
Target Bioclass
Enzyme
Family
UPRTase family
Subcellular location
Cytoplasm
Uniprot ID
Q96BW1
Ensemble ID
ENST00000373383.9
HGNC ID
HGNC:28334

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KPNYN SNV: p.N42D .
LNCaP clone FGC SNV: p.V253A .
TGBC1TKB SNV: p.P8L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C66(1.78)  LDD3325  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2058 C66(2.30)  LDD2253  [1]
 LDCM0023  KB03 A2058 C66(3.22)  LDD2670  [1]
 LDCM0024  KB05 UACC257 C66(1.78)  LDD3325  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (PYROXD1) Class-I pyridine nucleotide-disulfide oxidoreductase family Q8WU10
DNA-directed RNA polymerase II subunit RPB7 (POLR2G) Eukaryotic RPB7/RPC8 RNA polymerase subunit family P62487
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Enhancer of rudimentary homolog (ERH) E(R) family P84090
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoplasmin-3 (NPM3) Nucleoplasmin family O75607
Periplakin (PPL) Plakin or cytolinker family O60437
COMM domain-containing protein 1 (COMMD1) . Q8N668
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060