Details of the Target

General Information of Target

Target ID LDTP10120
Target Name PHD finger protein 21A (PHF21A)
Gene Name PHF21A
Gene ID 51317
Synonyms
BHC80; KIAA1696; PHD finger protein 21A; BHC80a; BRAF35-HDAC complex protein BHC80
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLHQLGDKPLTFPSPNSAMENGLDHTPPSRRASPGTPLSPGSLRSAAHSPLDTSKQPLC
QLWAEKHGARGTHEVRYVSAGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTV
NGFINTVITSLERRYDLHSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLM
GTGSLVFALPHFTAGRYEVELDAGVRTCPANPGAVCADSTSGLSRYQLVFMLGQFLHGVG
ATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELT
TESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSRGEA
SNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASE
AATLFGYLVVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLGILVFSLHCPSVP
MAGVTASYGGSLLPEGHLNLTAPCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATET
NVDGQKVYRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALT
ATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQN
SAMSRYILIMGLLYKVLGVLFFAIACFLYKPLSESSDGLETCLPSQSSAPDSATDSQLQS
SV
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
Uniprot ID
Q96BD5
Ensemble ID
ENST00000323180.10
HGNC ID
HGNC:24156

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C533(1.36)  LDD3383  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C514(0.98)  LDD1508  [2]
 LDCM0277  AC18 HEK-293T C514(0.94)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C514(1.06)  LDD1518  [2]
 LDCM0286  AC26 HEK-293T C514(0.97)  LDD1525  [2]
 LDCM0295  AC34 HEK-293T C514(0.96)  LDD1534  [2]
 LDCM0304  AC42 HEK-293T C514(0.93)  LDD1543  [2]
 LDCM0313  AC50 HEK-293T C514(0.97)  LDD1552  [2]
 LDCM0321  AC58 HEK-293T C514(1.03)  LDD1560  [2]
 LDCM0371  CL102 HEK-293T C532(0.85)  LDD1575  [2]
 LDCM0375  CL106 HEK-293T C532(1.05)  LDD1579  [2]
 LDCM0380  CL110 HEK-293T C532(0.90)  LDD1584  [2]
 LDCM0384  CL114 HEK-293T C532(0.85)  LDD1588  [2]
 LDCM0388  CL118 HEK-293T C532(1.12)  LDD1592  [2]
 LDCM0393  CL122 HEK-293T C532(1.06)  LDD1597  [2]
 LDCM0397  CL126 HEK-293T C532(1.01)  LDD1601  [2]
 LDCM0401  CL14 HEK-293T C532(0.96)  LDD1605  [2]
 LDCM0405  CL18 HEK-293T C514(0.99)  LDD1609  [2]
 LDCM0407  CL2 HEK-293T C532(0.93)  LDD1611  [2]
 LDCM0414  CL26 HEK-293T C532(1.18)  LDD1618  [2]
 LDCM0419  CL30 HEK-293T C514(0.98)  LDD1623  [2]
 LDCM0432  CL42 HEK-293T C514(1.02)  LDD1636  [2]
 LDCM0441  CL50 HEK-293T C532(1.25)  LDD1645  [2]
 LDCM0445  CL54 HEK-293T C514(0.86)  LDD1648  [2]
 LDCM0451  CL6 HEK-293T C514(0.91)  LDD1654  [2]
 LDCM0454  CL62 HEK-293T C532(1.08)  LDD1657  [2]
 LDCM0458  CL66 HEK-293T C514(1.01)  LDD1661  [2]
 LDCM0467  CL74 HEK-293T C532(0.97)  LDD1670  [2]
 LDCM0471  CL78 HEK-293T C514(1.05)  LDD1674  [2]
 LDCM0480  CL86 HEK-293T C532(1.08)  LDD1683  [2]
 LDCM0485  CL90 HEK-293T C514(0.82)  LDD1688  [2]
 LDCM0493  CL98 HEK-293T C532(0.84)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C532(1.23)  LDD1631  [2]
 LDCM0022  KB02 A2780 C533(1.05)  LDD2254  [1]
 LDCM0023  KB03 A2780 C533(1.01); C515(1.44)  LDD2671  [1]
 LDCM0024  KB05 OVCAR-5 C533(1.36)  LDD3383  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exosome complex component RRP43 (EXOSC8) RNase PH family Q96B26
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor Sp3 (SP3) Sp1 C2H2-type zinc-finger protein family Q02447
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Zyxin (ZYX) Zyxin/ajuba family Q15942
Four and a half LIM domains protein 2 (FHL2) . Q14192
Four and a half LIM domains protein 3 (FHL3) . Q13643
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402