Details of the Target

General Information of Target

Target ID LDTP10067
Target Name MARVEL domain-containing protein 3 (MARVELD3)
Gene Name MARVELD3
Gene ID 91862
Synonyms
MRVLDC3; MARVEL domain-containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILD
TAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKA
DLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRR
SSTTHVKQAINKMLTKISS
Target Bioclass
Transporter and channel
Subcellular location
Membrane
Function As a component of tight junctions, plays a role in paracellular ion conductivity.
Uniprot ID
Q96A59
Ensemble ID
ENST00000268485.8
HGNC ID
HGNC:30525

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IM95 Substitution: p.D74E .
J82 SNV: p.H31N .
KMCH1 SNV: p.Q202R .
NCIH1993 SNV: p.H31Q .
YSCCC SNV: p.R45P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C195(2.34)  LDD3486  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 VCaP C195(1.55)  LDD2652  [1]
 LDCM0023  KB03 VCaP C195(2.76)  LDD3069  [1]
 LDCM0024  KB05 VCaP C195(2.34)  LDD3486  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840