Details of the Target

General Information of Target

Target ID LDTP10011
Target Name Protein MAL2 (MAL2)
Gene Name MAL2
Gene ID 114569
Synonyms
Protein MAL2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCLRLGGLSVGDFRKVLMKTGLVLVVLGHVSFITAALFHGTVLRYVGTPQDAVALQYCVV
NILSVTSAIVVITSGIAAIVLSRYLPSTPLRWTVFSSSVACALLSLTCALGLLASIAMTF
ATQGKALLAACTFGSSELLALAPDCPFDPTRIYSSSLCLWGIALVLCVAENVFAVRCAQL
THQLLELRPWWGKSSHHMMRENPELVEGRDLLSCTSSEPLTL
Target Bioclass
Other
Family
MAL family
Subcellular location
Cell membrane
Function
Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
Uniprot ID
Q969L2
Ensemble ID
ENST00000614891.5
HGNC ID
HGNC:13634

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
rRNA methyltransferase 1, mitochondrial (MRM1) RNA methyltransferase TrmH family Q6IN84
Threonine--tRNA ligase, mitochondrial (TARS2) Class-II aminoacyl-tRNA synthetase family Q9BW92
FAST kinase domain-containing protein 4 (TBRG4) FAST kinase family Q969Z0
Glutamate decarboxylase 1 (GAD1) Group II decarboxylase family Q99259
Glutamate decarboxylase 2 (GAD2) Group II decarboxylase family Q05329
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Peroxynitrite isomerase THAP4 (THAP4) Nitrobindin family Q8WY91
Caspase-6 (CASP6) Peptidase C14A family P55212
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Serine/threonine-protein kinase Sgk1 (SGK1) AGC Ser/Thr protein kinase family O00141
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) Protein-tyrosine phosphatase family P43378
Serine hydroxymethyltransferase, mitochondrial (SHMT2) SHMT family P34897
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Ras-related protein Rab-37 (RAB37) Rab family Q96AX2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2) Succinate/malate CoA ligase beta subunit family Q9P2R7
V-type proton ATPase subunit e 1 (ATP6V0E1) V-ATPase e1/e2 subunit family O15342
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gap junction beta-1 protein (GJB1) Connexin family P08034
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Heat shock transcription factor, X-linked (HSFX1; HSFX2) HSF family Q9UBD0
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD160 antigen (CD160) . O95971
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Proteasome adapter and scaffold protein ECM29 (ECPAS) ECM29 family Q5VYK3
Endophilin-A2 (SH3GL1) Endophilin family Q99961
Macrosialin (CD68) LAMP family P34810
Transcription termination factor 3, mitochondrial (MTERF3) MTERF family Q96E29
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Mitochondrial dynamics protein MIEF1 (MIEF1) SMCR7 family Q9NQG6
Alpha-tocopherol transfer protein (TTPA) . P49638
Arfaptin-2 (ARFIP2) . P53365
NFAT activation molecule 1 (NFAM1) . Q8NET5
Protein PIMREG (PIMREG) . Q9BSJ6

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.