Details of the Target
General Information of Target
| Target ID | LDTP10004 | |||||
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| Target Name | Sodium-coupled neutral amino acid transporter 4 (SLC38A4) | |||||
| Gene Name | SLC38A4 | |||||
| Gene ID | 55089 | |||||
| Synonyms |
ATA3; NAT3; SNAT4; Sodium-coupled neutral amino acid transporter 4; Amino acid transporter A3; Na(+)-coupled neutral amino acid transporter 4; Solute carrier family 38 member 4; System A amino acid transporter 3; System N amino acid transporter 3
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| 3D Structure | ||||||
| Sequence |
MAAPSGGWNGVGASLWAALLLGAVALRPAEAVSEPTTVAFDVRPGGVVHSFSHNVGPGDK
YTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGKSYLYFTQFKAEVRGAEIEYA MAYSKAAFERESDVPLKTEEFEVTKTAVAHRPGAFKAELSKLVIVAKASRTEL |
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| Target Type |
Literature-reported
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| Target Bioclass |
Transporter and channel
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| Family |
Amino acid/polyamine transporter 2 family
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| Subcellular location |
Cell membrane
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| Function |
Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine.
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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STPyne Probe Info |
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K60(10.00) | LDD0277 | [1] | |