Details of the Target

General Information of Target

Target ID LDTP09997
Target Name Caveolae-associated protein 3 (CAVIN3)
Gene Name CAVIN3
Gene ID 112464
Synonyms
PRKCDBP; SRBC; Caveolae-associated protein 3; Cavin-3; Protein kinase C delta-binding protein; Serum deprivation response factor-related gene product that binds to C-kinase; hSRBC
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSKRPSYAPPPTPAPATQMPSTPGFVGYNPYSHLAYNNYRLGGNPGTNSRVTASSGITIP
KPPKPPDKPLMPYMRYSRKVWDQVKASNPDLKLWEIGKIIGGMWRDLTDEEKQEYLNEYE
AEKIEYNESMKAYHNSPAYLAYINAKSRAEAALEEESRQRQSRMEKGEPYMSIQPAEDPD
DYDDGFSMKHTATARFQRNHRLISEILSESVVPDVRSVVTTARMQVLKRQVQSLMVHQRK
LEAELLQIEERHQEKKRKFLESTDSFNNELKRLCGLKVEVDMEKIAAEIAQAEEQARKRQ
EEREKEAAEQAERSQSSIVPEEEQAANKGEEKKDDENIPMETEETHLEETTESQQNGEEG
TSTPEDKESGQEGVDSMAEEGTSDSNTGSESNSATVEEPPTDPIPEDEKKE
Target Bioclass
Other
Family
CAVIN family
Subcellular location
Cytoplasm
Function
Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2.
Uniprot ID
Q969G5
Ensemble ID
ENST00000303927.4
HGNC ID
HGNC:9400

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K185(3.58)  LDD0274  [1]
STPyne
 Probe Info  		K185(10.00); K197(10.00); K208(10.00); K84(8.79)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]
5E-2FA
 Probe Info  		H113(0.00); H91(0.00)  LDD2235  [3]
m-APA
 Probe Info  		H91(0.00); H71(0.00)  LDD2231  [3]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolin-1 (CAV1) Caveolin family Q03135
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolae-associated protein 1 (CAVIN1) CAVIN family Q6NZI2
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A) Small Tim family O60220
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Tropomyosin alpha-3 chain (TPM3) Tropomyosin family P06753
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Epidermal growth factor receptor substrate 15-like 1 (EPS15L1) . Q9UBC2
Melanoma-associated antigen 11 (MAGEA11) . P43364

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377