Details of the Target

General Information of Target

Target ID LDTP09995
Target Name LIM/homeobox protein Lhx4 (LHX4)
Gene Name LHX4
Gene ID 89884
Synonyms
LIM/homeobox protein Lhx4; LIM homeobox protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVQLYNLHPFGSQQVVPCKLEPDRFCGGGRDALFVAAGCKVEAFAVAGQELCQPRCAFST
LGRVLRLAYSEAGDYLVAIEEKNKATFLRAYVNWRNKRTENSRVCIRMIGHNVEGPFSKA
FRDQMYIIEMPLSEAPLCISCCPVKGDLLVGCTNKLVLFSLKYQIINEEFSLLDFERSLI
IHIDNITPVEVSFCVGYVAVMSDLEVLIVKLESGPKNGERVHHHPHKTNNRIRRTEEGIS
NEISQLESDDFVICQKPLELLGEKSEQSGLSVTLESTGLADEKRKYSHFQHLLYRRFAPD
ISSYVLSDDIKLHSLQLLPIYQTGSLTSDGKNLSQEKELLSLFCFFSLPHVGYLYMVVKS
VELMSVYQYPEKSQQAVLTPQFLHVITSNNLQCFTVRCSAAAAREEDPYMDTTLKACPPV
SMDVCALRIQLFIGLKAICHFKNHIILLTKAEPEAIPERRQSPKRLLSRKDTSVKIKIPP
VAEAGWNLYIVNTISPVQLYKEMVDYSNTYKTVKTQSCIHLLSEAHLLVRAALMDASQLE
PGEKAELLEAFKESCGHLGDCYSRLDSQHSHLTLPYYKMSGLSMAEVLARTDWTVEDGLQ
KYERGLIFYINHSLYENLDEELNEELAAKVVQMFYVAEPKQVPHILCSPSMKNINPLTAM
SYLRKLDTSGFSSILVTLTKAAVALKMGDLDMHRNEMKSHSEMKLVCGFILEPRLLIQQR
KGQIVPTELALHLKETQPGLLVASVLGLQKNNKIGIEEADSFFKVLCAKDEDTIPQLLVD
FWEAQLVACLPDVVLQELFFKLTSQYIWRLSKRQPPDTTPLRTSEDLINACSHYGLIYPW
VHVVISSDSLADKNYTEDLSKLQSLICGPSFDIASIIPFLEPLSEDTIAGLSVHVLCRTR
LKEYEQCIDILLERCPEAVIPYANHELKEENRTLWWKKLLPELCQRIKCGGEKYQLYLSS
LKETLSIVAVELELKDFMNVLPEDGTATFFLPYLLYCSRKKPLT
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA.
Uniprot ID
Q969G2
Ensemble ID
ENST00000263726.4
HGNC ID
HGNC:21734

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ATP probe
 Probe Info  		N.A.  LDD0199  [1]
YN-1
 Probe Info  		N.A.  LDD0447  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ferredoxin-2, mitochondrial (FDX2) Adrenodoxin/putidaredoxin family Q6P4F2
tRNA (guanine(10)-N2)-methyltransferase homolog (TRMT11) TRM11 methyltransferase family Q7Z4G4
ERO1-like protein alpha (ERO1A) EROs family Q96HE7
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Cyclin-dependent kinase 3 (CDK3) CMGC Ser/Thr protein kinase family Q00526
tRNA-splicing endonuclease subunit Sen54 (TSEN54) SEN54 family Q7Z6J9
Dehydrogenase/reductase SDR family member 1 (DHRS1) Short-chain dehydrogenases/reductases (SDR) family Q96LJ7
ADP-ribosylation factor-like protein 2 (ARL2) Arf family P36404
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (TSTD2) . Q5T7W7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C5 (HOXC5) Antp homeobox family Q00444
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Pituitary-specific positive transcription factor 1 (POU1F1) POU transcription factor family P28069
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490
Insulin gene enhancer protein ISL-1 (ISL1) . P61371
Insulin gene enhancer protein ISL-2 (ISL2) . Q96A47
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Zinc finger and BTB domain-containing protein 2 (ZBTB2) . Q8N680
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Biorientation of chromosomes in cell division protein 1-like 2 (BOD1L2) BOD1 family Q8IYS8
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
Myozenin-1 (MYOZ1) Myozenin family Q9NP98
Origin recognition complex subunit 6 (ORC6) ORC6 family Q9Y5N6
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
Centromere protein S (CENPS) TAF9 family Q8N2Z9
Coronin-1B (CORO1B) WD repeat coronin family Q9BR76
DDB1- and CUL4-associated factor 10 (DCAF10) WD repeat DCAF10 family Q5QP82
Axin-1 (AXIN1) . O15169
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (CHCHD2) . Q9Y6H1
DnaJ homolog subfamily B member 13 (DNAJB13) . P59910
INO80 complex subunit B (INO80B) . Q9C086
Kelch-like protein 38 (KLHL38) . Q2WGJ6
SCAN domain-containing protein 1 (SCAND1) . P57086
SH2 domain-containing protein 1A (SH2D1A) . O60880
U11/U12 small nuclear ribonucleoprotein 25 kDa protein (SNRNP25) . Q9BV90

References

1 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.