Details of the Target

General Information of Target

Target ID LDTP09983
Target Name Homogentisate 1,2-dioxygenase (HGD)
Gene Name HGD
Gene ID 3081
Synonyms
HGO; Homogentisate 1,2-dioxygenase; EC 1.13.11.5; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFLSKPSVYICLFTCVLQLSHSWSVNNFLMTGPKAYLIYSSSVAAGAQSGIEECKYQFAW
DRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNG
QLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTC
KCHGVSGSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIADTFRS
ISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRALGRWERRSCRRLCGDCGLAVEE
RRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCSRAERPRGGAAHKPGRKP
Target Bioclass
Enzyme
Family
Homogentisate dioxygenase family
Function Catalyzes the conversion of homogentisate to maleylacetoacetate.
Uniprot ID
Q93099
Ensemble ID
ENST00000283871.10
HGNC ID
HGNC:4892

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
IPM
 Probe Info  		C418(0.00); C338(0.00); C14(0.00)  LDD0241  [2]
DBIA
 Probe Info  		C418(1.86)  LDD3346  [3]
IA-alkyne
 Probe Info  		C418(0.00); C338(0.00); C14(0.00)  LDD0162  [4]
HHS-482
 Probe Info  		Y350(1.01)  LDD2239  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C51(2.13)  LDD1702  [6]
 LDCM0022  KB02 786-O C426(1.84)  LDD2247  [3]
 LDCM0023  KB03 786-O C426(2.22)  LDD2664  [3]
 LDCM0024  KB05 NCI-H1666 C418(1.86)  LDD3346  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homogentisate 1,2-dioxygenase (HGD) Homogentisate dioxygenase family Q93099
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 1 (TERF1) . P54274

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761