Details of the Target

General Information of Target

Target ID LDTP09937
Target Name Exostosin-like 1 (EXTL1)
Gene Name EXTL1
Gene ID 2134
Synonyms
EXTL; Exostosin-like 1; EC 2.4.1.224; Exostosin-L; Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostosis-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSH
HGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDE
FVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
Target Bioclass
Enzyme
Family
Glycosyltransferase 47 family
Subcellular location
Endoplasmic reticulum membrane
Function
Glycosyltransferase required for the biosynthesis of heparan-sulfate (HS). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity). Appears to lack GlcNAcT I and GlcAT-II activities.
Uniprot ID
Q92935
Ensemble ID
ENST00000374280.4
HGNC ID
HGNC:3515

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C169(3.02)  LDD3484  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 UACC-62 C169(4.26)  LDD2650  [1]
 LDCM0023  KB03 UACC-62 C169(5.27)  LDD3067  [1]
 LDCM0024  KB05 UACC-62 C169(3.02)  LDD3484  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840