Details of the Target

General Information of Target

Target ID LDTP09910
Target Name Deoxyribonuclease-1-like 2 (DNASE1L2)
Gene Name DNASE1L2
Gene ID 1775
Synonyms
DHP1; DNAS1L2; Deoxyribonuclease-1-like 2; EC 3.1.21.-; DNase I homolog protein DHP1; Deoxyribonuclease I-like 2; DNase I-like 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVTAQAARRKERVLCLFDVDGTLTPARQKIDPEVAAFLQKLRSRVQIGVVGGSDYCKIA
EQLGDGDEVIEKFDYVFAENGTVQYKHGRLLSKQTIQNHLGEELLQDLINFCLSYMALLR
LPKKRGTFIEFRNGMLNISPIGRSCTLEERIEFSELDKKEKIREKFVEALKTEFAGKGLR
FSRGGMISFDVFPEGWDKRYCLDSLDQDSFDTIHFFGNETSPGGNDFEIFADPRTVGHSV
VSPQDTVQRCREIFFPETAHEA
Target Bioclass
Enzyme
Family
DNase I family
Subcellular location
Cytoplasm
Function
Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.
Uniprot ID
Q92874
Ensemble ID
ENST00000320700.10
HGNC ID
HGNC:2958

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C42(1.40)  LDD3345  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 MCF-7 C42(1.16)  LDD2452  [2]
 LDCM0023  KB03 CAL-148 C42(1.60)  LDD2702  [2]
 LDCM0024  KB05 NCI-H1650 C42(1.40)  LDD3345  [2]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840