Details of the Target

General Information of Target

Target ID LDTP09900
Target Name Bcl-2-like protein 2 (BCL2L2)
Gene Name BCL2L2
Gene ID 599
Synonyms
BCLW; KIAA0271; Bcl-2-like protein 2; Bcl2-L-2; Apoptosis regulator Bcl-W
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPTGFVAPILCVLLPSPTREAATVASATGDSASERESAAPAAAPTAEAPPPSVVTRPEPQ
ALPSPAIRAPLPDLYPFGTMRGGGFGDRDRDRDRGGFGARGGGGLPPKKFGNPGERLRKK
KWDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQ
YVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLE
RGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEICIA
TPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWP
KEVRQLAEDFLRDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENK
TIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASR
GLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIKVLEEA
NQAINPKLMQLVDHRGGGGGGGGRSRYRTTSSANNPNLMYQDECDRRLRGVKDGGRRDSA
SYRDRSETDRAGYANGSGYGSPNSAFGAQAGQYTYGQGTYGAAAYGTSSYTAQEYGAGTY
GASSTTSTGRSSQSSSQQFSGIGRSGQQPQPLMSQQFAQPPGATNMIGYMGQTAYQYPPP
PPPPPPSRK
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Bcl-2 family
Subcellular location
Mitochondrion membrane
Function Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
TTD ID
T03755
Uniprot ID
Q92843
DrugMap ID
TTQ79W8
Ensemble ID
ENST00000250405.10
HGNC ID
HGNC:995
ChEMBL ID
CHEMBL4677

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL78 SNV: p.L134M .
KELLY SNV: p.P33S .
REH SNV: p.V127M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C29(1.43)  LDD3342  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C29(1.89)  LDD2254  [1]
 LDCM0023  KB03 A2058 C29(1.40)  LDD2670  [1]
 LDCM0024  KB05 NCI-H1155 C29(1.43)  LDD3342  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Sphingosine-1-phosphate lyase 1 (SGPL1) Group II decarboxylase family O95470
Microsomal glutathione S-transferase 2 (MGST2) MAPEG family Q99735
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Thioredoxin-related transmembrane protein 1 (TMX1) . Q9H3N1
Transporter and channel
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin (STOM) Band 7/mec-2 family P27105
Apoptosis regulator BAX (BAX) Bcl-2 family Q07812
Bcl-2 homologous antagonist/killer (BAK1) Bcl-2 family Q16611
Bcl-2-like protein 11 (BCL2L11) Bcl-2 family O43521
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Claudin-7 (CLDN7) Claudin family O95471
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) Eukaryotic ATPase subunit F6 family P18859
Syncytin-2 (ERVFRD-1) Gamma type-C retroviral envelope protein family P60508
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
Pannexin-1 (PANX1) Pannexin family Q96RD7
Transmembrane protein 179B (TMEM179B) TMEM179 family Q7Z7N9
Solute carrier family 35 member E3 (SLC35E3) TPT transporter family Q7Z769
Zinc transporter ZIP2 (SLC39A2) ZIP transporter (TC 2.A.5) family Q9NP94
Transmembrane protein 139 (TMEM139) . Q8IV31
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Class A basic helix-loop-helix protein 9 (BHLHA9) . Q7RTU4
Transcription factor 4 (TCF4) . P15884
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 151 (GPR151) G-protein coupled receptor 1 family Q8TDV0
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein C-I (APOC1) Apolipoprotein C1 family P02654
Apolipoprotein C-IV (APOC4) Apolipoprotein C4 family P55056
Apoptosis-stimulating of p53 protein 2 (TP53BP2) ASPP family Q13625
Bcl-2-binding component 3, isoforms 1/2 (BBC3) Bcl-2 family Q9BXH1
Bcl-2-modifying factor (BMF) Bcl-2 family Q96LC9
Bcl2-associated agonist of cell death (BAD) Bcl-2 family Q92934
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Low-density lipoprotein receptor-related protein 10 (LRP10) LDLR family Q7Z4F1
Ankyrin repeat and SAM domain-containing protein 6 (ANKS6) . Q68DC2
Bcl-2-interacting killer (BIK) . Q13323
BH3-interacting domain death agonist (BID) . P55957
Chondrolectin (CHODL) . Q9H9P2
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
G0/G1 switch protein 2 (G0S2) . P27469
Protein BNIP5 (BNIP5) . P0C671
Protein Bop (RTL10) . Q7L3V2
Protein KASH5 (KASH5) . Q8N6L0
Sushi domain-containing protein 3 (SUSD3) . Q96L08

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abt-263 Small molecular drug D06ETI
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Navitoclax Small molecular drug DB12340
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid27744724-compound-18 Small molecular drug D0TU3N

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019