Details of the Target

General Information of Target

Target ID LDTP09897
Target Name Ectodysplasin-A (EDA)
Gene Name EDA
Gene ID 1896
Synonyms
ED1; EDA2; Ectodysplasin-A; Ectodermal dysplasia protein; EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPCRREEEEEAGEEAEGEEEEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQHSP
ASPCGPPGAPLRAPGPLAAAVPADKARSPAVPLLLPPALAETVGPAPPGVLRCALGDRGR
VRGRAAPYCVAELATGPSALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRGAAASR
RLQQRRGSQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGPL
SAPVHEPPSPRSPRAACSDPGASGRAQLRTGDGVLVPGS
Target Bioclass
Cytokine and receptor
Family
Tumor necrosis factor family
Subcellular location
Secreted; Cell membrane
Function
Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. May also play a role in cell adhesion.; [Isoform 1]: Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R.; [Isoform 3]: Binds only to the receptor EDA2R.
Uniprot ID
Q92838
Ensemble ID
ENST00000338901.4
HGNC ID
HGNC:3157

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KPNYN Insertion: p.A30GfsTer28 .
MCC13 SNV: p.L42F; p.P203S .
MEWO Substitution: p.R72L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD2156  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dolichol kinase (DOLK) Polyprenol kinase family Q9UPQ8
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) V-ATPase proteolipid subunit family P27449
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) Amino acid/polyamine transporter 2 family Q9NVC3
Myelin and lymphocyte protein (MAL) MAL family P21145
Membrane-spanning 4-domains subfamily A member 13 (MS4A13) MS4A family Q5J8X5
NIPA-like protein 3 (NIPAL3) NIPA family Q6P499
Oligosaccharyltransferase complex subunit OSTC (OSTC) OSTC family Q9NRP0
Cardiac phospholamban (PLN) Phospholamban family P26678
Peripheral myelin protein 22 (PMP22) PMP-22/EMP/MP20 family Q01453
Transmembrane protein 50B (TMEM50B) UPF0220 family P56557
Transmembrane protein 60 (TMEM60) . Q9H2L4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysophosphatidic acid receptor 3 (LPAR3) G-protein coupled receptor 1 family Q9UBY5
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cortexin-3 (CTXN3) Cortexin family Q4LDR2
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Epithelial membrane protein 1 (EMP1) PMP-22/EMP/MP20 family P54849
Epithelial membrane protein 3 (EMP3) PMP-22/EMP/MP20 family P54852
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Transmembrane protein 42 (TMEM42) . Q69YG0

References

1 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019