Details of the Target

General Information of Target

Target ID LDTP09892
Target Name Protein kinase C-binding protein NELL1 (NELL1)
Gene Name NELL1
Gene ID 4745
Synonyms
NRP1; Protein kinase C-binding protein NELL1; NEL-like protein 1; Nel-related protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAA
AGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTP
PRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKE
RQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPR
YETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQ
NSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSG
LEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSA
RDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFD
PKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH
DILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFS
VIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSK
EPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNR
YYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.
TTD ID
T22368
Uniprot ID
Q92832
DrugMap ID
TT7H4BF
Ensemble ID
ENST00000357134.10
HGNC ID
HGNC:7750

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.V237M .
DU145 SNV: p.E344K .
HCT15 SNV: p.E265G; p.E736Ter .
HDQP1 SNV: p.S751R .
HEC1B SNV: p.C462Y .
KPL1 SNV: p.E417V .
MCAS SNV: p.N448T .
MCF7 SNV: p.E417V .
MEWO SNV: p.D377N; p.P381L .
NCIH2170 SNV: p.S590C .
NCIH2172 SNV: p.D478Y; p.Q714H .
OCUG1 SNV: p.C462G .
OZ SNV: p.V530G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C304(1.60); C273(1.81)  LDD3413  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 IPC-298 C304(1.17); C273(1.29)  LDD2400  [1]
 LDCM0023  KB03 RVH-421 C304(1.65); C273(2.19)  LDD2996  [1]
 LDCM0024  KB05 RVH-421 C304(1.60); C273(1.81)  LDD3413  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
All-trans retinoic acid-induced differentiation factor (ATRAID) . Q6UW56

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060