Details of the Target
General Information of Target
| Target ID | LDTP09868 | |||||
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| Target Name | Retinol dehydrogenase 5 (RDH5) | |||||
| Gene Name | RDH5 | |||||
| Gene ID | 5959 | |||||
| Synonyms |
HSD17B9; RDH1; SDR9C5; Retinol dehydrogenase 5; EC 1.1.1.209; EC 1.1.1.315; EC 1.1.1.53; 11-cis retinol dehydrogenase; 11-cis RDH; 11-cis RoDH; 9-cis retinol dehydrogenase; 9cRDH; Short chain dehydrogenase/reductase family 9C member 5
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| 3D Structure | ||||||
| Sequence |
MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPPPPPGPGAASASAAPPTASPGPER
RPPPASAPAPQPAPTPSVGSSFFSSLSQAVKQTAASAGLVDAPAPAPAAARKAKVLLVVD EPHADWAKCFRGKKVLGDYDIKVEQAEFSELNLVAHADGTYAVDMQVLRNGTKVVRSFRP DFVLIRQHAFGMAENEDFRHLIIGMQYAGLPSINSLESIYNFCDKPWVFAQLVAIYKTLG GEKFPLIEQTYYPNHKEMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVALTQT YATAEPFIDSKYDIRVQKIGNNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDTC SEMFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITELVISKMNQLLSR TPALSPQRPLTTQQPQSGTLKDPDSSKTPPQRPPPQGGPGQPQGMQPPGKVLPPRRLPPG PSLPPSSSSSSSSSSSAPQRPGGPTTHGDAPSSSSSLAEAQPPLAAPPQKPQPHPQLNKS QSLTNAFSFSESSFFRSSANEDEAKAETIRSLRKSFASLFSD |
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| Target Bioclass |
Enzyme
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| Family |
Short-chain dehydrogenases/reductases (SDR) family
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| Subcellular location |
Endoplasmic reticulum membrane
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| Function |
Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal. Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C267(0.92) | LDD3389 | [1] | |
Competitor(s) Related to This Target