Details of the Target

General Information of Target

Target ID LDTP09862
Target Name Keratin, type I cuticular Ha5 (KRT35)
Gene Name KRT35
Gene ID 3886
Synonyms
HHA5; HKA5; KRTHA5; Keratin, type I cuticular Ha5; Hair keratin, type I Ha5; Keratin-35; K35
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESTPSRGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRML
FLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRI
ALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLS
QAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQL
SFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGT
VHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGIT
AQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFEL
LLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS
Target Bioclass
Other
Family
Intermediate filament family
Uniprot ID
Q92764
Ensemble ID
ENST00000246639.7
HGNC ID
HGNC:6453

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		D106(0.77)  LDD2208  [1]
DBIA
 Probe Info  		C310(1.79)  LDD3345  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 MKN-1 C310(0.91)  LDD2497  [2]
 LDCM0023  KB03 MKN-1 C310(1.01)  LDD2914  [2]
 LDCM0024  KB05 NCI-H1650 C310(1.79)  LDD3345  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840