Details of the Target

General Information of Target

Target ID LDTP09798
Target Name Testican-2 (SPOCK2)
Gene Name SPOCK2
Gene ID 9806
Synonyms
KIAA0275; TICN2; Testican-2; SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPTAAAPIISSVQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQ
QEVRELLGRLDLGNRTKMGQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIG
GHAIYKVEDTNMIYIPNDSVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLT
VLRMPLEMLKSEMTQNRQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKS
TVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVE
TEQILCDASVMSFTAGSYSSYVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAHVAALH
FDQMFQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAK
YTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSILRPDEKWNELGGCVIPTGRLQTG
ILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDT
LSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHP
TEGKPHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPEVIKHLPLPYDEVICAVNLKKLI
VKKFHKYEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTVGIDPSPFTVRKPDE
TGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREEEGSVSQRSTPVK
MTDAGDSAKVTENVVQPMKELYGINLSDGLSEEDFSIYSRFVQLGQSQHKQDKNSQQPCS
RCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDSSMYRE
YIRNRYL
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix
Function May participate in diverse steps of neurogenesis. Binds calcium.
Uniprot ID
Q92563
Ensemble ID
ENST00000317376.8
HGNC ID
HGNC:13564

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.V65A .
JHH6 SNV: p.C355Y .
JURKAT SNV: p.P35L; p.R369C .
LS123 SNV: p.G32C .
MDAMB453 SNV: p.C289W .
MEWO SNV: p.A103V .
NCIH716 SNV: p.M253V .
TOV21G SNV: p.C166F; p.W356L .
UMUC3 Deletion: p.A244PfsTer122 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C101(2.62)  LDD3365  [1]
IA-alkyne
 Probe Info  		C313(6.63); C246(12.65)  LDD1704  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell-activated C313(6.63); C246(12.65)  LDD1704  [2]
 LDCM0023  KB03 CAL-51 C166(1.56); C101(1.78)  LDD2705  [1]
 LDCM0024  KB05 OVCAR-3 C101(2.62)  LDD3365  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.